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Tag: Deregulated nutrient sensing

June 08, 2020
Researchers have concluded a human trial using niacin, a very old vitamin discovered over 80 years ago, and have shown that it can increase the presence of an energy compound essential to cellular function. Niacin and NAD+ Niacin is a form of water-soluble vitamin B3 and has been known since American biochemist Conrad Elvehjem identified...
June 04, 2020
In this informative episode of X10, Nicola explains how failing to properly sense nutrients is a problem that comes with old age, and he brings up the myriad, complicated details of the relationships between cellular mechanisms.
January 10, 2020
A new open-access review published in Trends in Cell Biology sheds light on both the causes and consequences of genomic instability, the DNA damage that is one of the primary hallmarks of aging. Sources of Damage A substantial portion of genomic instability is caused by unwanted reactions with chemicals that we need to survive. Oxidation...
November 01, 2019
The Journal Club returned for a Halloween special, and Dr. Oliver Medvedik looked at a recent paper showing that a combination of three drugs had a synergistic effect and increased lifespan greatly in fruit flies. The drugs all target parts of the nutrient sensing system, which controls metabolism, and its deregulation is proposed to be...
October 21, 2019
The Journal Club returns for a Halloween special, and this time around, Dr. Oliver Medvedik is taking an in-depth look at a recent paper showing that a combination of three drugs had a synergistic effect and increased lifespan greatly in fruit flies. The drugs all target parts of the nutrient sensing system which controls metabolism,...
August 21, 2019
Today, we want to spotlight a recent study showing that boosting nicotinamide adenine dinucleotide (NAD+) levels in mice prevents age-related hearing loss. What is β-Lapachone? β-Lapachone is a quinone-containing compound that was originally isolated from the lapacho tree in South America. It is worth noting that this tree has been used as a herbal medicine...