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Tag: Deregulated Nutrient Sensing

December 03, 2020
A key gene mediating the effect of dietary restriction on longevity has been identified, improving our understanding of the link between the two and raising the prospect of more targeted therapeutic interventions. Less is more Dietary restriction is one of the most reliable ways to increase longevity, increasing lifespan in species from fruit flies to...
September 07, 2020
Alpha-ketoglutarate (AKG) has long been a popular sports supplement and is often used in the bodybuilding world, but interest in this molecule has now reached the aging research field due to its central role in metabolism. History of alpha-ketoglutarate Alpha-ketoglutarate (AKG) was discovered in 1937 by Hans Adolf Krebs and William Arthur Johnson at the...
June 08, 2020
Researchers have concluded a human trial using niacin, a very old vitamin discovered over 80 years ago, and have shown that it can increase the presence of an energy compound essential to cellular function. Niacin and NAD+ Niacin is a form of water-soluble vitamin B3 and has been known since American biochemist Conrad Elvehjem identified...
June 04, 2020
In this informative episode of X10, Nicola explains how failing to properly sense nutrients is a problem that comes with old age, and he brings up the myriad, complicated details of the relationships between cellular mechanisms.
January 10, 2020
A new open-access review published in Trends in Cell Biology sheds light on both the causes and consequences of genomic instability, the DNA damage that is one of the primary hallmarks of aging. Sources of Damage A substantial portion of genomic instability is caused by unwanted reactions with chemicals that we need to survive. Oxidation...
November 01, 2019
The Journal Club returned for a Halloween special, and Dr. Oliver Medvedik looked at a recent paper showing that a combination of three drugs had a synergistic effect and increased lifespan greatly in fruit flies. The drugs all target parts of the nutrient sensing system, which controls metabolism, and its deregulation is proposed to be...