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Tag: Deregulated Nutrient Sensing

Mitochondrion
A new study conducted by a team of Japanese scientists and published in Scientific Reports details how cells can have their damaged mitochondria destroyed and replaced with healthy ones, offering a potential solution to the problem of mitochondrial dysfunction. Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to...
AKG may be a useful supplement for slowing down aging.
Alpha-ketoglutarate (AKG) has long been a popular sports supplement and is often used in the bodybuilding world, but interest in this molecule has now reached the aging research field due to its central role in metabolism. What is alpha-ketoglutarate? AKG is a naturally occurring endogenous intermediary metabolite and part of the Krebs cycle, which means...
Respiratory tract infection
A new study published in The Lancet shows the results of Phase 2a and Phase 3 clinical trials for the effectiveness of mTOR inhibition on bolstering the aging immune system against respiratory illnesses. Immunosenescence increases disease risk As we grow older, our immune systems become increasingly dysfunctional and less able to defend us from the...
X10 Caloric Restriction Thumbnail
In this episode of X10, we discuss the practice of caloric restriction along with its effects, which involve the TOR signaling pathway, epigenetic alterations, and DNA repair.  Sources Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. (2009) Caloric restriction delays...
Welcome to part two of a two-part series exploring NAD+ biology; you can find part one here. There are already a myriad of excellent reviews on NAD+ biology in general [1-3], so, in this article, we will be mainly focusing on the NAD+ precursor nicotinamide mononucleotide (NMN). NMN and synthesis of NAD+ NMN can be...
This is part one of a two-part article where we take a look at NAD+ biology, its history, how it relates to the biology of aging, and the potential for therapeutic interventions via the so-called NAD+ precursors. What is NAD+? Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It is a...