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Tag: Cellular Reprogramming

Fluorescent cells
A team of Chinese researchers has described a novel method of illuminating pluripotent stem cells in a paper published in Aging. How and why Yamanaka Factors and Partial Cellular ReprogrammingDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells. While this discovery showed...
Mouse Tumor
Scientists have shown that partial cellular reprogramming can significantly increase the already impressive regenerative capacity of the liver and protect this crucial organ from a potentially lethal injury [1]. Why can't we regrow limbs? Cellular reprogramming induces de-differentiation of somatic cells back into pluripotent stem cells: a 'factory reset' that erases cell-specific software and hence...
Oil of Snake
It seems bizarre that in 2022, some biotech companies interested in doing something about aging are still saying that they are not. Cellular rejuvenation seems to be the latest buzzword and an attempt to rebrand and escape the stigma of anti-aging. Genentech is another cellular rejuvenation company Recently, researchers at the Salk Institute, in collaboration...
Mouse genes
Scientists have shown that in vivo partial cellular reprogramming can be safe and effective in an animal model, although the rejuvenation was mostly limited to long-term treatments and two tissue types [1]. There and back again Cellular reprogramming sounds like a technology from Star Trek, and it is undeniably futuristic. Our tissues mostly consist of...
Rainbow Clocks
In a preprint published in bioRxiv, Morgan Levine and colleagues have identified and grouped 5,717 epigenetic CpG sites into 12 different modules, conducting an in-depth examination into how epigenetic clocks work. Epigenetic Clocks - What are they?An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA...
New Biotech
In a pre-print paper that has not yet been peer reviewed, a group of researchers presented a new highly efficient method of partial cellular reprogramming [1]. Young from old Our cells age, and old cells differ from young ones in multiple ways, including gene expression, telomere length, and protein milieu. However, old germline cells can...