November 01, 2022
Scientists have shown that continuous low-dose induction of reprogramming factors and a single early life reprogramming treatment both significantly increase lifespan and healthspan in progeroid mice while altering their epigenetic landscape [1]. In vivo reprogramming Cellular reprogramming is the process of treating cells with compounds that nudge them towards a pluripotent state. The classical...
October 28, 2022
Turn.bio has announced that its proprietary cellular reprogramming technology was able to significantly increase the proliferative and cytotoxic potential of premanufactured CAR-T cells in vitro. Turn.bio, a developer of mRNA-based cellular reprogramming technologies, has announced preliminary results from its current trial. The announcement was made by the company's co-founder, Prof. Vittorio Sebastiano, at the New...
May 16, 2022
A team of Chinese researchers has described a novel method of illuminating pluripotent stem cells in a paper published in Aging. How and why Yamanaka Factors and Partial Cellular ReprogrammingDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells. While this discovery showed...
April 29, 2022
Scientists have shown that partial cellular reprogramming can significantly increase the already impressive regenerative capacity of the liver and protect this crucial organ from a potentially lethal injury [1]. Why can't we regrow limbs? Cellular reprogramming induces de-differentiation of somatic cells back into pluripotent stem cells: a 'factory reset' that erases cell-specific software and hence...
March 30, 2022
It seems bizarre that in 2022, some biotech companies interested in doing something about aging are still saying that they are not. Cellular rejuvenation seems to be the latest buzzword and an attempt to rebrand and escape the stigma of anti-aging. Genentech is another cellular rejuvenation company Recently, researchers at the Salk Institute, in collaboration...
March 11, 2022
Scientists have shown that in vivo partial cellular reprogramming can be safe and effective in an animal model, although the rejuvenation was mostly limited to long-term treatments and two tissue types [1]. There and back again Cellular reprogramming sounds like a technology from Star Trek, and it is undeniably futuristic. Our tissues mostly consist of...
