January 24, 2023
In a new paper published in Nature, scientists have found that raising NAD+ levels via supplementation with nicotinamide mononucleotide (NMN) activates SIRT1 to dampen metastasis in mouse TNBC models [1]. A double-edged sword NAD+ is a ubiquitous co-enzyme that facilitates numerous processes in our body, from energy production to DNA repair. Its levels decline with...
January 23, 2023
The results of a Phase 1 clinical trial of allogeneic CAR T cell therapy against multiple myeloma have been published today in Nature Medicine, and they appear to be promising. B cells, engineered T cells, and lymphodepletion Multiple myeloma is a cancer of the plasma B cells, which are formed in the blood marrow and...
January 03, 2023
Emma Teeling is a professor at University College of Dublin, and her research focuses on bats. In this interview, Emma explains why many bats, despite having tiny body sizes and leading very metabolically demanding lifestyles, are so amazingly long-lived. Will we ever be able to learn these animals' secrets of beating the odds? Emma is...
December 12, 2022
A team of researchers from multiple Japanese universities has found a way to genetically enhance T cells against solid tumors, as published today in Nature Biomedical Engineering. A focus on signals This highly in-depth paper begins with a discussion of signaling in the response of chimeric antigen receptor (CAR) T cells, as good signals are...
November 25, 2022
In a new study published in the journal Cancer Research, Israeli scientists have found that by increasing the metabolic activity of healthy cells, exercise likely pitches them against cancer cells in a battle for nutrients, which slows cancer progression [1]. Higher metabolic activity Physical activity provides many health benefits, and it can even lower the...
November 22, 2022
A paper published in the journal Biosensors and Bioelectronics has caused a stir in the longevity community by showing that nicotinamide riboside (NR), a precursor to NAD+, makes tumors more aggressive in a mouse model [1]. Using a novel diagnostic tool In this new paper, the researchers employed a well-known technique called bioluminescence imaging [2]...
