Tag: AMPK

Researchers publishing in Aging have discovered that an energy metabolism compound is associated with a protein that suppresses amyloid beta in a mouse model of Alzheimer's. The compounds involved The researchers describe nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) as a key co-factor for energy metabolism. This compound is involved in creating NAD+, which is essential in...

We take a look at berberine, a popular supplement in the life extension community that is often touted as being similar to metformin. What is berberine? Berberine is an ammonium salt from the protoberberine group of benzylisoquinoline alkaloids. It is part of a group of naturally occurring alkaloids that mostly contain basic nitrogen atoms. Berberine...

A new study conducted by a team of Japanese scientists and published in Scientific Reports details how cells can have their damaged mitochondria destroyed and replaced with healthy ones, offering a potential solution to the problem of mitochondrial dysfunction. Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to...

Experiments by researchers in China and the US have shown that the smell of food is enough to reduce the lifespan gains caused by dietary restriction in nematodes. By unraveling the genetic and neurological network behind this, the team found evidence that the same might hold true in mammals. Dietary restriction is more than a...

A new study in Molecular Cell has shown that the benefits of hypoxia may be derived from a suppression of the inflammatory SASP. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially...

The results of a recent study suggest that fisetin appears to reduce the development of bleomycin-induced pulmonary fibrosis [1]. Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. The earliest record of isolated fisetin dates back to 1833 from the smoke bush (Rhus cotinus). Its basic chemical characteristics were...