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Tag: Alzheimer's

Mouse test
In a new study published in Pharmacology Biochemistry and Behavior, researchers have shown that a combination of two compounds targeting different autophagy pathways is effective in fighting the pathological mechanism of Alzheimer's disease in a mouse model [1]. Cleaning up is a big deal The accumulation of "junk", such as misfolded proteins and damaged organelles,...
Cellular membrane
Scientists have learned that plasmalogens, obscure but important lipids, serve as a mediator of neurogenesis and synaptic health and can reverse age-related cognitive decline in mice [1]. Plasmalogens and membranes Plasmalogens are a subtype of phospholipids, the molecules that cellular membranes are mostly made of. Plasmalogens are especially abundant in brain, heart, and immune cells,...
Lithium Pills
A study published in Plos Medicine has shown that lithium decreases the risk of developing dementia and some of its subtypes, including Alzheimer's disease and vascular dementia [1]. Enigmatic but effective According to WHO, Alzheimer's disease and other dementias were the second-leading cause of death in high-income countries and the seventh globally in 2019. To...
Alzheimer's MRIs
The risk of Alzheimer’s disease goes up with age, and the number of people living with Alzheimer's is growing. While it is known to be associated with the loss of proteostasis, it has also been found to be associated with epigenetic alterations. An advanced online preprint in bioRxiv was published by Dr. Morgan E. Levine...
Assisted living
A paper published in the journal of the Alzheimer's Association has revealed the results of a Phase 1 clinical trial of stem cells for Alzheimer's disease. Using stem cells for their signals While stem cells, including the mesenchymal stem cells (MSCs) of which Lomecel-B consists, are well-known for their ability to differentiate into other cells,...
Common Aggregate
Research funded by the National Institutes of Health and published in Cell has thoroughly described a little-known amyloid aggregate that accumulates in the brains of people suffering from multiple proteostasis-related neurological disorders. Three classes of pathology, one protein fragment The authors of this study list three different classes of neurodegenerative protein disorders: TDP-43 proteinopathies, such...