Tag: Alzheimer's

Scientists have developed a custom-made molecule that targets a post-translationally modified kinase linked to Alzheimer’s, improving symptoms in a murine model of the disease [1]. A novel approach to neutralizing proteins MAPK is a family of kinases involved in numerous cellular processes. One member of this family, p38 MAPK, is known to be activated by...

In a new study published in Nature Aging, scientists have shown that targeted ablation of neuronal APOE4, which produces the ApoE4 protein, significantly protects against Alzheimer’s disease in a mouse model [1]. The dreadful allele An infamous variant of the APOE gene, APOE4, is the strongest risk factor for late-onset Alzheimer’s disease [2]. People heterozygous...

In Nature Biomedical Engineering, a team of researchers has published an innovative method of making tau tangles and amyloid beta visible in the near infrared, allowing doctors and researchers to see through bone with relatively simple equipment. Current methods are difficult There are three main approaches to diagnosing Alzheimer's and other brain disorders in living...

A study published in the Annals of Translational Medicine has shown the effects of niacin supplementation on a mouse model of Alzheimer's and outlined the genes involved. What is Niacin? Benefits and Side EffectsNiacin is a form of vitamin B3. It was discovered in 1937 by Conrad Elvehjem and originally used to treat pellagra, a...

Researchers publishing in Nutrients have shown that adding a strain of lactic acid bacteria to the gut flora of older, memory-impaired people partially alleviates their memory problems. A specific anti-inflammatory bacterium The researchers begin their paper by noting that mild cognitive impairment (MCI) is associated with memory loss and is frequent precursor of Alzheimer's disease...

A paper published in Cell Metabolism has reported on a metabolic shift in neurons derived from patients with Alzheimer's disease, showing that they express a cancer-like phenotype [1]. Induced neurons Rather than attempting to harvest live neurons from Alzheimer's patients, the researchers chose to create induced neurons (iNs) from the fibroblasts of these patients, comparing...