News

A recent study saw researchers associated with Cellvie demonstrate significant improvements to mitochondria and muscle function in aged mice by injecting additional mitochondria [1]. Mitochondrial dysfunction is a reason we age Why We Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species...

A placebo-controlled Phase 1/2 trial conducted in East Shanghai has found that administering umbilical cord-derived mesenchymal stem cells reduces frailty in older people. Stem cells against frailty These researchers begin by defining frailty as "a state of heightened vulnerability to potential stressors as a consequence of reduction in physiological reserves across multiple systems" [1]. This...

A study published in Human Nutrition & Metabolism found that prolonged intermittent fasting causes the expression of genes involved in autophagy, the inflammasome, and senescence to change [1]. Fasting your way to better health and longevity? Previous research has linked fasting to delaying the onset of age-related diseases and longevity along with positive outcomes in...

Last month has brought forward a lot of exciting news in the longevity industry, including our own upcoming merger with SENS. Here's what's happened in April. LEAF News SENS Research Foundation and Lifespan.io Announce Intent to Merge, Forming a Novel Longevity Entity: SENS Research Foundation and Lifespan.io (Lifespan Extension Advocacy Foundation) have unveiled plans to...

Scientists have identified the proteins FOXF1 and its downstream target FZD4 as potential targets for treating lung cancer. Upregulating them helps to normalize vasculature in the tumor area and suppresses this lethal type of cancer [1]. Lung cancer and vasculature Lung cancer remains one of the deadliest diseases in the world, accounting for 22% of...

In Aging Cell, researchers have published evidence that downregulating a key aspect of lipid metabolism harms mitochondrial function, but only in cells taken from younger people. Fat regulation at the cellular level Perilipins (PLINs) are proteins that regulate the use of fats (lipids) within cells. This paper focuses on PLIN2, which has previously been investigated...