Tag: Cellular Senescence

Researchers publishing in the Journal of Clinical Investigation have developed a new method of screening for compounds, and they found one that appears to directly attack senescent cells involved in lung fibrosis. A disease of senescence What Are Senolytics? Senotherapeutics for Senescent CellsSenolytics work by targeting one of several pro-survival pathways that senescent cells use...

Scientists have demonstrated that CAR T cells can be employed against senescent intestinal stem cells, improving regeneration and ameliorating age-related symptoms such as “leaky gut” [1]. Cell-on-cell warfare Cellular senescence is a heterogeneous phenomenon in which cells stop dividing and malfunction, driving up inflammation. While senescent cells play a positive role in certain contexts, such...

Scientific Reports has published a study that used a computational approach to identify natural senotherapeutics that have a similar impact on gene expression as a known senotherapeutic drug, dasatinib [1]. Drug combinations for better treatments Cellular senescence, a state in which cells cannot divide anymore but are still metabolically active and often display senescence-associated secretory...

The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...

A new study claims that low-frequency ultrasound can reverse aspects of replicative and chemically induced senescence in vitro [1]. Not just chemicals The age-related increase in senescent cell burden is thought to contribute to many processes of aging. Most of the attempts to deal with it involve senolytics: drugs that eliminate senescent cells. However, it...

Recent research published in Immunity and Ageing suggests that chitosan can be used as a potential treatment to alleviate some of the aging processes in ovaries [1]. Quickly declining fertility Mother Nature has imposed some tough challenges on human females. They need to make the decision about motherhood sooner rather than later, as research has...