Tag: Stem Cell Exhaustion

Researchers publishing in Cell Proliferation have described factors that appear to give old muscle stem cells the ability to effectively proliferate and differentiate for a very long time. When renewal runs out Why we Age: Stem Cell ExhaustionStem cell exhaustion is the age-related deficiency of stem cells. This particular hallmark is directly responsible for many...

In a preprint paper published on bioRxiv, researchers including João Pedro de Magalhães have gotten a glimpse at how stemness declines across tissues with aging. Using AI to get a grasp on stemness Why we Age: Stem Cell ExhaustionStem cell exhaustion is the age-related deficiency of stem cells. This particular hallmark is directly responsible for...

In a new study published in Aging Cell, researchers have shown that two promising anti-aging agents, the antibiotic rapamycin and the anti-diabetic drug metformin, reverse aging in a population of intestinal stem cells [1]. The aging intestine Older people are more prone to gastrointestinal problems [2]. Moreover, aging is a major risk factor for various...

A pair of researchers from Stanford University have published a detailed review of the current state of CAR T immune cell therapies in Nature. A new state of the art in fighting cancer Chimeric antigen receptor (CAR) is a technology that allows researchers to alter T cells to attack specifically chosen targets. As of this...

Researchers publishing in the Nature journal npj Regenerative Medicine have zeroed in on a major reason behind stem cell exhaustion and determined that inhibiting it has significantly rejuvenative effects. A protein that suppresses stem cells In both humans and mice, the protein Cdc42 increases with aging. This is because its natural inhibitor, Cdc42GAP, decreases in...

Researchers publishing in Cell Stem Cell have found that the mitochondrial protein OPA1 is an integral, regulatory part of muscle stem cell activation, the process by which muscle stem cells proliferate and become active muscle tissue (myogenesis) [1]. Another piece of the puzzle We have recently reported on the effects of mitochondrial fusion and fission...