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Tag: Stem Cell Exhaustion

Mouse brain maze
December 23, 2020
A new article published in Aging and Disease has taken a look at what two stem cell-activating growth factors can do in aged mice with Alzheimer's-like pathology. Alzheimer's disease (AD) is perhaps the most age-related of all age-related diseases. Perhaps not coincidentally, it has also been the most stubborn disease to develop treatments for. One...
Alexander Fedintsev
December 03, 2020
At Ending Age-Related Diseases 2020, Dr. Alexander Fedintsev of the Institute of Biology at Komi Science Center gave a talk about collagen glycation. Cross-links caused by advanced glycation end-products such as glucosepane stiffen the extracellular matrix, leading to systemic problems. Dr. Fedintsev provides evidence showing that the stiffened ECM leads to stem cell depletion, cellular...
July 03, 2020
Researchers have found that blocking the activity of a single gene causes other cell types to become dopamine-producing neurons, a type of neuron that Parkinson’s disease destroys. What is Parkinson's disease? Parkinson's disease is a progressive, age-related, neurodegenerative disease that mainly affects the motor system and thus movement. Symptoms start gradually; sometimes it begins with...
X10 stem cell exhaustion
June 18, 2020
Your stem cells, which repopulate the cells that are lost during life, are depleted in old age. In this informative episode of X10, Giuliano describes what causes this integrative hallmark to occur.
June 15, 2020
Senescent cell accumulation is a likely reason we age, but removing some populations of specialized cells that have turned senescent may have negative consequences, according to a new study. What are senescent cells? As you get older, more and more of your cells enter into a state known as cellular senescence. Senescent cells no longer...
March 17, 2020
Researchers from Johns Hopkins Medicine have successfully used stem cells to repair diabetic damage to retinal blood vessels. The researchers believe that their findings will advance regenerative approaches that seek to reverse conditions such as diabetic retinopathy and other eye diseases that lead to blindness. Induced pluripotent stem cells (iPSCs) have been around for well...