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Tag: Stem Cell Exhaustion

A study conducted by researchers at the University of Taipei in Taiwan has shown that the ginseng derivative Rg1 decreases the cellular senescence marker p16INK4a in fitness-trained men 24 hours after exercise. An experiment to link p16INK4a, aging, exercise, and Rg1 The cell cycle inhibitor p16INK4a, which is also a well-known biomarker of senescent cells,...
Elderly muscle
Muscular degradation with age isn’t the result of a decline in the intrinsic regenerative ability of muscles, according to new research [1].  Instead, sarcopenia is likely due to changes in the muscle microenvironment that reduce repair and regeneration. Declining muscles Age-related muscle loss can begin as early as a person’s fourth decade, and sarcopenia can...
Mouse brain maze
A new article published in Aging and Disease has taken a look at what two stem cell-activating growth factors can do in aged mice with Alzheimer's-like pathology. Alzheimer's disease (AD) is perhaps the most age-related of all age-related diseases. Perhaps not coincidentally, it has also been the most stubborn disease to develop treatments for. One...
Alexander Fedintsev
At Ending Age-Related Diseases 2020, Dr. Alexander Fedintsev of the Institute of Biology at Komi Science Center gave a talk about collagen glycation. Cross-links caused by advanced glycation end-products such as glucosepane stiffen the extracellular matrix, leading to systemic problems. Dr. Fedintsev provides evidence showing that the stiffened ECM leads to stem cell depletion, cellular...
Researchers have found that blocking the activity of a single gene causes other cell types to become dopamine-producing neurons, a type of neuron that Parkinson’s disease destroys. What is Parkinson's disease? Parkinson's disease is a progressive, age-related, neurodegenerative disease that mainly affects the motor system and thus movement. Symptoms start gradually; sometimes it begins with...
X10 stem cell exhaustion
Your stem cells, which repopulate the cells that are lost during life, are depleted in old age. In this informative episode of X10, Giuliano describes what causes this integrative hallmark to occur.