Tag: Stem Cell Exhaustion

In a preprint published in bioRxiv, a team of Singaporean researchers, including Jan Gruber, has found that a combination of stem cell rejuvenation and senescent cell removal is synergistically more effective than either alone. Different but related aspects of aging Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent...

Researchers publishing in Aging have reported that licochalcone A (LA), a flavonoid that originates from Chinese licorice, restores human adipose-derived stem cells (hADSCs) in cell culture. Reported positive effects Previous research on Licochalcone A has discovered that it has anti-inflammatory and anti-tumor effects [1], reduces obesity in mice [2], and protects against liver failure through...

Researchers have found that hematopoietic stem cells lose function as they grow larger and that rapamycin can alleviate this effect [1]. When cells become obese When it comes to cells, size matters, with stem cells being on the smaller side [2]. Scientists have suspected for quite some time that this wasn’t a coincidence, but the relationship...

A review published in Frontiers in Cell and Developmental Biology has explained how DNA damage and its accompanying immune response lead to changes in the microenvironment of stem cells, causing a decline in their function. Why we Age: Stem Cell ExhaustionStem cell exhaustion is the age-related deficiency of stem cells. This particular hallmark is directly...

Scientists showed that hair loss happens partially as a result of stem cells escaping from hair follicles. They also shot a stunning time-lapse video of the process. The stem cell cycle Stem cells reside in “stem cell compartments” in various tissues. By differentiating into multiple types of cells upon demand, they contribute to tissue regeneration....

A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their exhaustion The reviewers began by discussing stem cell exhaustion, a hallmark of aging and a common concern of aging research that we have covered extensively....