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Tag: RNA

Effect of AMD
A paper published in Aging explains the relationship of long noncoding RNAs, which change with aging, to age-related macular degeneration (AMD). A disease of deposits and aging This paper begins with a discussion of AMD and its prevalence. AMD is the most common cause of vision loss in people over 70 years old [1]. Its...
Disagreeing clocks
A paper published in Aging goes into detail about the proteins and RNA pieces that increase and decrease with aging, suggesting a multiple-clock approach to biomarkers. Blood proteins change with age The researchers start out by discussing existing clocks based on such measurements as imaging [1] and epigenetic methylation [2], which is the most well-known...
Heart DNA
Scientists from Duke University have found a way to make adult fibroblasts differentiate into cardiomyocytes, which might help develop better heart attack treatments [1]. The imperfect repair HeartThe heart is a four-chambered organ located between our lungs. Blood is pumped by the heart through two loops, one to the lungs, oxygenating the blood, and the...
RNA transcription
Research published yesterday in Nature has described one way in which RNA sequencing changes in the cell with age and how this may be linked to lifespan. Transcriptional elongation Transcriptional elongation is a fundamental biological process, as it affects the basic steps involved in the production of RNA, which is responsible for executing the instructions...
New Hallmarks
Publishing in Aging five months after their panel discussion in Copenhagen, many well-known researchers have explained their reasons for wishing to add new hallmarks of aging to the existing paradigm. A new addition to an old paradigm What is Aging? The Nine Reasons We AgeAging is a series of processes that include direct damage, accumulation...
Lorna Harries Interview
Lorna Harries is a Professor of Molecular Genetics at the University of Exeter Medical School. She is also the CSO and R&D lead at SENISCA Ltd. Like many other companies, and as evidenced by the name, SENISCA targets senescent cells, albeit using an unusual mRNA-based approach. After Lorna gave a fascinating talk at our Ending...