August 22, 2023
A paper published in Aging explains the relationship of long noncoding RNAs, which change with aging, to age-related macular degeneration (AMD). A disease of deposits and aging This paper begins with a discussion of AMD and its prevalence. AMD is the most common cause of vision loss in people over 70 years old [1]. Its...
August 18, 2023
Scientists have found that EGCG and curcumin, two well-known antioxidants, are effective both alone and especially in combination in a mouse model of cognitive decline induced by oxidative stress [1]. Not the usual stress Oxidative stress results mostly from molecules called reactive oxygen species (ROS), which are byproducts of normal chemical reactions in the body....
July 31, 2023
A paper published today in Nature Metabolism has described a method of genetically engineering cells to respond to electrical stimuli, allowing for on-demand gene expression. Finding a better trigger Despite its futuristic outlook, this line of research is built upon previous work. The idea of an implantable gene switch to command cells in order to...
May 31, 2023
Scientists publishing in Antioxidants have reported that increasing glutathione levels with GlyNAC, a supplement that combines glycine and cysteine, significantly reverses age-related cognitive decline in naturally aged mice [1]. GlyNAC vs oxidative stress Oxidative stress caused by reactive oxygen species (ROS) is known to be one of the upstream causes of aging and contributes to...
March 13, 2023
A paper published in Experimental Gerontology has provided a fresh and detailed look at the effects of oxidative stress on longevity. Revisiting an old theory The free radical theory of aging, which purports that reactive oxygen species (ROS) are the core driver of aging, was developed all the way back in 1956 [1] and expanded...
January 24, 2023
In a new paper published in Nature, scientists have found that raising NAD+ levels via supplementation with nicotinamide mononucleotide (NMN) activates SIRT1 to dampen metastasis in mouse TNBC models [1]. A double-edged sword NAD+ is a ubiquitous co-enzyme that facilitates numerous processes in our body, from energy production to DNA repair. Its levels decline with...
