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Tag: Reactive Oxygen Species

Heart Inflammation
A team of Chinese researchers has outlined the cellular link between age-related inflammation (inflammaging) and the physical aging of heart muscle cells (cardiomyocytes). NLRP3 and why it matters We have previously discussed the NLRP3 inflammasome, which releases inflammatory cytokines upon exposure to irritants [1], including reactive oxygen species (ROS) [2]. The researchers hypothesized that ROS,...
Unexpected treasure
Researchers have found that zoledronate, a drug used to treat osteoporosis, has unexpected life-extending properties in human beings, and they confirmed these findings in a fruit fly study. The original unexpected findings Zoledronate is a biophosphonate, a drug used to strengthen bones and reduce the risk of osteoporosis-related bone fractures. It is well-absorbed into the...
Lab rat and flasks
Glucosamine is a polysaccharide that naturally occurs in cartilaginous joint tissues and is involved in protein and lipid synthesis. Glucosamine is also present in other tissues, such as skin, nails, bones, and ligaments. Synovial fluid contains glucosamine and occupies the space between joints, helping to reduce the friction of joint surfaces. Glucosamine is commonly taken...
Lab mouse
A new mouse study has found that injecting healthy mitochondria from young mice into older mice improves learning and memory, skeletal muscle function, and immune system activity [1]. The Aging Mitochondria Mitochondria are incredibly important components of our cells, as they produce energy in the form of ATP, the "molecular unit of currency" of intracellular...
In a new study, researchers have identified a direct link between mitophagy and inflammation. Aging is accompanied by rising levels of oxidative stress, which is primarily caused by our cellular power plants, the mitochondria. As we age, our mitochondria start to produce an increasing amount of oxidized molecules known as reactive oxygen species (ROS), which...
Mitochondria
The mitochondria are the powerhouses of the cell, producing ATP, a kind of universal energy used in cellular functions. Mitochondrial dysfunction is an important part of the aging process. As cells age, the effectiveness of the respiratory chain diminishes, increasing electron leakage and reducing ATP generation [1]. As mitochondria become more dysfunctional with age, there...