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Tag: NAD+

March 31, 2021
Scientists have alleviated symptoms of the rare premature aging disease ataxia-telangiectasia using NAD+ supplementation in a mouse model [1]. This success deepens our understanding of the role NAD+ plays in aging. The ubiquitous facilitator The coenzyme nicotinamide adenine dinucleotide (NAD+) is one of the foundations of life as we know it, and it may have...
NMN molecule
March 26, 2021
Nicotinamide adenine dinucleotide is essential for life The coenzyme nicotinamide adenine dinucleotide (NAD+) serves critical functions in our cells, such as electron transport, cell signaling, and DNA repair. Found in the cells of all mammals, NAD+ is essential for life and is linked closely to metabolism and aging. Accumulating evidence suggests that NAD+ systemically declines...
Cells signalling
March 19, 2021
There has been a lot of attention given to the NAD precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), sold as dietary supplements, to restore nicotinamide adenine dinucleotide (NAD) levels. However, a new study suggests that there could be a new game in town with the arrival of reduced nicotinamide mononucleotide (NMNH). Introducing nicotinamide adenine...
Diagram of NADH
March 15, 2021
What is nicotinamide adenine dinucleotide? Nicotinamide adenine dinucleotide (NAD+) is a key coenzyme found in all living cells. It is a dinucleotide, which means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base, and the other contains nicotinamide. NAD+ is essential for life, one of the most...
March 10, 2021
Welcome to part two of a two-part series exploring NAD+ biology; you can find part one here. There are already a myriad of excellent reviews on NAD+ biology in general [1-3], so, in this article, we will be mainly focusing on the NAD+ precursor nicotinamide mononucleotide (NMN). NMN and synthesis of NAD+ NMN can be...
March 02, 2021
This is part one of a two-part article where we take a look at NAD+ biology, its history, how it relates to the biology of aging, and the potential for therapeutic interventions via the so-called NAD+ precursors. What is NAD+? Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It is a...