June 06, 2022
On this episode of Lifespan News, Ryan O'Shea discusses a study showing that NMN increases NAD+ in human beings. Script The results of a recently published human trial suggest that NMN may have an anti-aging effect in humans, but are these results to be believed? We’ll explore the study, and some additional information you’ll want...
June 02, 2022
The data from a multicenter NMN clinical trial have been published with some very modest but still interesting results [1]. What is NMN? NMN is short for nicotinamide mononucleotide, a naturally occurring molecule present in all species. It is a precursor of nicotinamide adenine dinucleotide (NAD+), a molecule that may be useful in slowing down...
April 05, 2022
Scientists from Mayo Clinic have significantly extended lifespan in male mice by inhibiting the enzyme CD38, which lowers NAD levels [1]. The age-related decline of nicotinamide dinucleotide (NAD) has been associated with various metabolic abnormalities, age-related diseases, and fitness loss. Nicotinamide Adenine DinucleotideNicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells. It...
March 16, 2022
A miniature review of clinical trials targeting aging was published in Frontiers in Aging by Dr. Morten Scheibye-Knudsen and colleagues [1]. This review specifically focuses on interventions that have shown strong clinical evidence that they impact aging. Caloric restriction We have previously discussed the effects of caloric restriction (CR) in reducing immunosenescence, improving DNA repair,...
February 22, 2022
In a study published in Nature Aging, a group of scientists has shown that NAD+ levels are correlated not only with age but with physical activity, with elder athletes rivaling normal young adults [1]. NAD: small, crucial, age-related Nicotinamide adenine dinucleotide (NAD) is as important as it is tiny. As its name suggests, this molecule...
December 24, 2021
Scientists have found that long-term supplementation with NMN, an NAD+ precursor, dramatically slows reproductive aging in mice by improving mitochondrial function and alleviating senescence [1]. Reproductive aging affects women relatively early in life, but like other types of aging, this one has been considered normal until recently, and no serious attempts have been made to...
