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Tag: Immune system

Infectious disease
A meta-analysis published in GeroScience has shown that the well-studied drug rapamycin has positive effects on infection in mice, but dietary restriction seems to worsen the problem. Aging, immunity, and interventions This paper begins with the well-known information that aging impairs the immune system, harming its effectiveness against infectious diseases [1] while causing systemic inflammation...
Blood cancer
New research published in Cancer Discovery has outlined a potential new method of using senescent cells to encourage the immune system to attack cancer [1]. Senescent cancer cells and immune clearance Cellular senescence is a stress response [2], and cancer cells within tumors undergo significant stress: they lose access to oxygen and nutrients, they divide...
Boost
Scientists have found that when T cells are activated by antigen-presenting cells, the activating cells donate chunks of their telomeres to the T cells, preventing senescence [1]. Imperfect protection Telomeres are sequences of TTAGGG repeats at the ends of our chromosomes that protect their integrity. Because of the way in which our somatic cells copy...
B cells
Researchers have recently explored why B cells become less efficient as we age, analyzing how their behavior changes when they are transplanted from aged mice into young mice [1]. The immune system is a comprehensive defense system Our immune systems protect us from disease and are vital to the healthy function of every organ and...
Cancer cell
Publishing in Nature, scientists have found that sodium lactate boosts the T cell-mediated anti-cancer immune response, leading to significant inhibition of tumor growth [1]. A double-edged sword As a means of energy production, the Krebs cycle is preferred by most cells in most conditions. However, there is also a seemingly less efficient and more ancient...
Immunoglobin G
In a new review published in Clinica Chimica Acta, researchers from the University of Zagreb discuss immunoglobulin G glycans, the changes that their composition undergoes with aging, and their potential as biomarkers of aging [1]. Glycans are not AGEs One of the review's co-authors is Prof. Gordan Lauc, who gave a presentation on the importance...