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Tag: Frailty

Wheelchair exercise
Today in GeroScience, researchers have published an analysis of a cohort study, concluding that adherence to physical activity recommendations can mitigate the increased mortality associated with disability. Simply being able to live In this paper, disability refers to impediments to the basic activities of daily living (ADLs), such as moving, dressing, showering, and eating. Disability...
Ancient clock
An accepted manuscript in the Journals of Gerontology has described how a third-generation epigenetic clock is a predictor  of future frailty. Are epigenetic and physiological metrics connected? This paper begins with an examination of two different methods of measuring aging processes. The first is the well-known epigenetic clocks, and this paper lists several, including the...
Treadmill mouse
A paper published in Aging has detailed how gene therapy has been used to treat sarcopenia in wild-type mice, and the results are positive. A lack of effective treatments As expected with papers of this kind, the researchers begin by discussing frailty and sarcopenia, the age-related loss of muscle tissue that is associated with decreased...
Flavonoids
In a new prospective cohort study, a higher intake of flavonols, and quercetin in particular, was linked to a significant decrease in the risk of frailty [1]. Flavonoids: not just flavor Flavonoids are a class of polyphenolic compounds that include flavanols, flavonols, flavones, anthocyanins, and some others. Flavonoids are abundant in plant-based foods, including fruits,...
Muscle factor
A paper published today in Nature Aging has shown that a macrophage-regulating factor has a significant impact on muscle regeneration. Healing slows with aging The researchers note two key reasons for the decline of regenerative abilities with aging. The first is stem cell exhaustion, the gradual depletion of stem cells and ensuing lack of functional...
Elderly lifting
Research published in Nature Metabolism has described PCYT2, an enzyme essential for muscle function, and how it declines with aging. A necessary lipid synthesizer in muscle Human beings need PCYT2 as part of the Kennedy pathway to synthesize two critical components of the phosopholipid membrane that surrounds cells [1]. People with genetic deficiencies of PCYT2...