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Tag: Frailty

Strong mouse
In their publication in Stem Cell Research & Therapy, a team of researchers has shown how effective mesenchymal stromal cells (MSCs) are in a mouse model. Multipotent cells with multiple uses As multipotent stem cells, MSCs can differentiate into several different cell types, including fat cells, neurons, and bone cells [1]. The researchers point to...
Seniors walking
Researchers publishing in Aging Cell have shown a relationship between mitochondrial dysfunction and mobility decline in older adults. A changing longitudinal study Since 1958, a team of researchers from the National Institute on Aging Intramural Research program has been conducting the Baltimore Longitudinal Study of Aging (BLSA). The BLSA, which has been used for other...
Osteoarthritis
A new study shows that even low levels of physical activity are very good for your muscles, bones, and joints, but exercising too much can potentially harm you [1]. The unholy trinity Sarcopenia, osteoporosis, and osteoarthritis are the trio of age-related diseases that affect, respectively, muscles, bones, and joints. Sarcopenia is the progressive loss of...
Running mouse
A team of researchers publishing in Cell Death & Disease has found that the age-related decline of mitochondrial calcium uptake family member 3 (MICU3), a regulator of mitochondrial function, is associated with sarcopenia, the aging-associated loss of muscle. Why mitochondria control their calcium uptake The calcium ion, Ca2+, is vital in mitochondrial metabolism and interacts...
Exercise clock
A new, three-year study published in The Journals of Gerontology: Series A examined the relationship between epigenetic clocks and physical performance in older women. Epigenetic clocks and biological age  Epigenetic Clocks - What are they?An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine...
Longeveron
Longeveron has just announced the first data from its Phase 2b clinical trial that targets frailty with Lomecel-B, an MSC-based cell therapy. A longevity strategy built in More and more, biotech start-ups are applying longevity strategies to their therapeutic pipelines. Among them, Longeveron stands out as one of the few companies taking a cell-based approach....