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Category: LifeXtenShow

X10 Caring about Aging
March 01, 2021
In this episode of X10, we discuss three reasons why people don't care about curing aging. Getting people to care about elderly dying from a deadly disease is relatively easy, but getting them to care about the cause of their frailty and immune susceptibility, aging itself, is a bit different.  Sources The elderly are...
LifeXtenShow on cellular rejuvenation
February 15, 2021
In this episode of X10, Nicola explains a way to epigenetically reset cells using the OSKM Yamanaka factors, putting them back into a pluripotent stem cell state. These factors have also been experimentally shown to restore cells to youth in other ways, and it is also possible to carefully use these factors to make cells...
LifeXtenShow on the tones of DNA
February 04, 2021
In this episode of X10, Nicola explains methylation in the context of language tones, showing how DNA methylation leads to DNA interpretations being slightly different between cells. He also introduces the idea of epigenetic clocks and discusses how gene expression, epigenetic alterations, and methylation are related. HELP SPREAD THE WORD Please connect with us on...
LifeXtenShow depicts chromatin as books
January 21, 2021
On this episode of LifeXtenShow, Sedeer explains histones in the context of epigenetic alterations, one of the hallmarks of aging, using a library of books as an analogy. As we age, our histones change how accessible our DNA is, altering how our cells read our genome and make proteins. Some of these proteins are also...
LifeXtenShow on tangled DNA
January 07, 2021
LifeXtenShow has returned! In this first episode of the new year, Sedeer explains how chromatin is bundled up in the nucleus and how aging turns this bundle into a tangle, leading to genomic instability, epigenetic alterations, and age-related diseases.
X10 channel announcement
November 16, 2020
LifeXtenShow,'s channel for all things life extension, now has its own channel! Featuring talks, quizzes, and in-depth explainers, this Youtube series gives you all the intricate details of aging research in a way that's easy to understand. Browse previous episodes to see what this channel is all about, and stay tuned to learn more!