Rejuvenation Roundup July 2022

Organizations and research teams continue to make strides.


Rejuvenation Roundup JulyRejuvenation Roundup July

Ending Age-Related Diseases 2022 will occur in less than two weeks, but that’s far from the only thing happening this month, and there’s plenty that happened last month as well. Here’s the latest rejuvenation news from July.


Health Benefits of Cocoa: Ryan O’Shea explains how more evidence has emerged for the heart health benefits of cocoa; it appears that cocoa may lower the risk of death by cardiovascular disease in aging adults.

Age of Elected Officials: Ryan O’Shea jumps into the political arena by focusing on how rejuvenation biotechnology might make Elon Musk’s age-related comments not age well themselves.

Exercise, Metformin, and VO2max: This episode presents a recent study showing that metformin blunts the impact of exercise on performance. Metformin is a commonly prescribed diabetes drug, but it is also popular among biohackers and life extensionists who take it for what they believe to be its longevity benefits.


Extracellular Matrix in Aging with Professor Collin Ewald: Dr. Collin Ewald is a molecular biologist and a professor at the Swiss Federal Institute of Technology in Zürich (ETH). At ETH, Collin leads the Laboratory of Extracellular Matrix (ECM) Regeneration. Here, his research focuses on age-related ECM remodeling and related longevity interventions.


Eterna is a clothing company with a focus on longevity.

Vadim GladyshevVadim Gladyshev on the Fundamentals of Aging: Vadim Gladyshev is a Professor of Medicine at Brigham and Women’s Hospital and Harvard Medical School, and he is one of the most prominent figures in geroscience today. We discussed various competing hypotheses on the nature of aging, the lack of the unified theory of aging and the need for one, and several fascinating papers.

Rejuvenation Roundup Podcast

Ryan O’Shea of Future Grind hosts this month’s podcast, showcasing the events and research discussed here.

Journal Club

Rejuvenating old human skin through VEGF-A: This month, Dr. Oliver Medvedik took a look at a recent paper in which researchers showed that old human skin was rejuvenated when implanted in young mice.


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Advocacy and Analysis

Longevity Will Become a Mainstream Part of Drug Development: Joppe Nieuwenhuis, Innovation Scout at Rejuveron Life Sciences, discusses his views about the future of longevity and rejuvenation research and how it will merge with current medical frameworks and systems.

Research Roundup

Rejuvenated skinOld Human Skin Rejuvenated When Implanted in Young Mice: Publishing in Science, researchers have transplanted old human skin to young mice and witnessed a robust rejuvenation cascade that is probably triggered by vascular growth.

Rejuvenating the Brain with Transplanted Astrocytes: A new study published in Stem Cell Research and Therapy has shown that rejuvenating the astrocyte niche in the aged brains of mice leads to improved nervous system function at both the cellular and organismal levels.

Vascular brainMetformin, Rapamycin, NMN, and Vascular Cognitive Impairment: A study published in Frontiers in Neurology has detailed how three well-known longevity-associated compounds affect vascular cognitive impairment (VCI) in a rat model that mimics arterial occlusion in human beings.

Fruits and Vegetables Linked to Fewer Cognitive Disorders: A meta-analysis published in Frontiers in Nutrition has found that intake of fruits and vegetables is negatively correlated with cognitive decline in older adults. Sixteen different studies were used for this meta-analysis, and not all of them measured fruit and vegetable comsuption the same way or measured the same endpoints.


Red grapesShort-Term Resveratrol Reverses Ovarian Aging in Mice: Researchers have shown that resveratrol reverses several features of ovarian aging in mice while activating most sirtuins and boosting mitochondrial health. In many mammals, including humans, ovarian aging is premature compared to other systems.

AI-Powered Novel Therapeutic Target Discovery: A new study conducted by Insilico Medicine in collaboration with leading aging research institutions has identified novel therapeutic targets for amyotrophic lateral sclerosis, a devastating age-associated neurodegenerative disease.

OrgansDifferent Tissues’ Proteins Age in Different Ways: An in-depth preprint published in bioRxiv has thoroughly described how separate tissues lose proteostasis in different ways. The researchers compared protein accumulation between old and young killifish, examining the brain, gut, heart, liver, muscle, skin, and testis.

Mild COVID Can Cause Protracted Neurological Problems: Researchers have shown that even mild SARS-CoV-2 infection can cause lingering neurological symptoms. These findings might shed light on the infamous “long COVID”. COVID survivors sometimes experience cognitive symptoms, such as “brain fog”, that can linger for months.

Standing mouseThe Importance of Mitochondria in Joint Health: Publishing in Aging, a team of Spanish researchers has found that changing the mitochondria of standard Black 6 mice, without any other modifications, leads to marked improvements in joint health.

Bioreactor-Grown Mitochondria for Potential Anti-Aging: Researchers from the University of Connecticut, Stanford University, Université Laval Quebec, and NSU Florida have helped test large-scale exogenous mitochondrial transplants in animal disease models and in-vitro human cells. The results suggest broad efficacy for targeting the immune system, brain, retina, liver, skin, and systemic anti-aging.

Diet and exerciseExercise and Healthy Diet Cannot Replace Each Other: In a large-scale study, scientists have shown that exercise and good diet affect mortality independently, showing that you need both to stay healthy. Exercise is good for you, and so is a healthy diet. Moreover, those are probably the only currently available interventions with a proven effect on healthspan and lifespan.

Fighting Muscle Atrophy with Gene Editing: In a new study published in Journal of Nanobiotechnology, researchers prevented muscle atrophy both in vitro and in vivo by delivering a CRISPR-Cas9 gene editing system packaged in engineered extracellular vesicles.

Not what you wantVitamin D Supplements May Make Alzheimer’s Worse: In a study with data from about 16,000 people, researchers publishing in Aging Cell have found that administering Vitamin D to Alzheimer’s patients may actually make the problem worse.

Oocytes Age Slowly by Remodeling Electron Transport: Scientists have discovered that immature oocytes maintain their youth by shutting down one of the protein complexes that produce energy in mitochondria.

NK cellNAD+ Helps Natural Killer Cells to Fight Cancer: Scientists have shown that the effectiveness of natural killer cells, a crucial component of the immune system, is directly linked to NAD+ levels. Discovering and fighting cancer cells is energetically expensive.

Blueberry Extract Reduces Aging Biomarkers in Rat Livers: A study published in Oxidative Medicine and Cellular Longevity has shown how blueberry extract moderately improves several age-related biomarkers in the livers of aging male rats.

Old politicianPoliticians Live Longer Than Most People: By analyzing historical data, scientists have shown that politicians, an example of an elite group, have enjoyed longer than average life expectancy since about 1950.

Social Frailty Is Correlated with All-Cause Mortality: Scientists have shown that social frailty – a composite index based on income level, household status, and social activity – significantly affects all-cause mortality in the elderly, with poverty being the predominant factor.

GlutamineGlutamine Supplementation Has Anti-Aging Potential: A new study published in Frontiers of Pharmacology has shown that glutamine deprivation might speed up aging while glutamine supplementation reduces oxidative stress-induced senescence in mice.

Loss of IGF-1 May Contribute to Neurovascular Aging: Researchers publishing in GeroScience have reported that the age-related decline in IGF-1 levels is associated with neurovascular aging. However, given the weak correlations, even if there is a causal relationship, it is likely to be only one of many factors.

Future ClockEpigenetic Age Acceleration Is Correlated with Mortality: In an important step for the longevity field, scientists have found that epigenetic age acceleration, as measured by four popular methylation clocks, is correlated with aging and mortality in humans.

Acetyl-cholinesterase-inhibitors slow cognitive decline and decrease overall mortality in older patients with dementia: Among older people with dementia, treatment with these drugs was associated with a slower cognitive decline and with reduced mortality, after a mean follow-up of almost eight years.

Targeted Plasmalogen Supplementation in Cognitively Impaired Persons: Changes in cognition and mobility were statistically significant versus a random outcome. Baseline DHA-containing plasmalogen levels were not predictive of clinical response. DHA-plasmalogens were well tolerated at all dosages, and no adverse reactions were observed.

Age estimation from sleep studies using deep learning predicts life expectancy: Sleep disturbances increase with age and are predictors of mortality. In this study, the researchers present deep neural networks that estimate age and mortality risk through polysomnograms.

Mitochondrial Transfusion Improves Mitochondrial Function in the Hippocampus of Aged Mice: Methods of mitochondrial transfusion should be further tested to treat a variety of human diseases or disorders and to slow down or reverse processes of aging.

Anti-Aging Effect of the Stromal Vascular Fraction/Adipose-Derived Stem Cells in a Mouse Model of UVB-Induced Skin Aging: Changes in the epidermal cell layer were clearly observed after 7 days of treatment. After 28 days of treatment, the dermal tissue was thickened, and the collagen content and proportion were improved.

Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice: The researchers hold that a senolytic approach might help to overcome the clinical limitations of current chemotherapy treatments.

Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice: These findings may provide evidence that senolytics can eliminate the senescent cells and facilitate microvascular formation in the marrow space of the bony endplate.

The importance of elders: Extending Hamilton’s force of selection to include intergenerational transfers: These results formalize the theory that longevity can be favored under socioecological conditions characterized by parental and alloparental care funded through transfers of mid- to late-life production surpluses.

The damage-independent evolution of aging by selective destruction: Selective destruction could provide a proximal cause of aging that is both consistent with the gene expression hallmarks of aging and independent of accumulating damage.

News Nuggets

Rejuveron Press ReleaseSecond Rejuveron Company Transitions into Clinical Stage: Rejuveron Life Sciences AG (‘Rejuveron’), a Zürich-based biotechnology company developing therapies to promote healthy aging, is pleased to announce that the first participant has been treated in Endogena Therapeutics’ phase 1/2a clinical study of its lead product, EA-2353, a photoreceptor regeneration treatment for retinitis pigmentosa (RP).

The Evandro Fang Lab Receives VitaDAO’s Third IP-NFT Funding: On June 15, 2022, VitaDAO hosted an online IP-NFT Transfer Ceremony honoring its third project funded via an IP-NFT: Evandro Fang Lab. The finances delivered to this lab will go toward further research into identifying novel mitophagy inducers that contribute to healthy brain aging and longevity.

Investment decisionVitaDAO Invests $1 Million into Biotech Company Turn.Bio: Marking one of VitaDAO’s largest investments to date, the decentralized organization has allocated $1,000,000 in funding to Turn.Bio. This company, also known as Turn Biotechnologies, plans to undertake preclinical efficacy testing of mRNA therapeutics intended to induce self-healing of the skin and eyes.

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