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In Cell, a team of researchers, including the founders of the biotech company HepaRegeniX, has published a paper on HRX215, a molecule that encourages liver regeneration. When the liver doesn't regenerate The researchers note that the liver has a "nearly unlimited regenerative potential" under healthy circumstances. However, when its microenvironment changes due to damage, this...
Pharmaceuticals on shelf
Scientists have used a huge database to find links between existing drugs and human lifespan. Only 14 of more than 400 showed a positive correlation [1]. Reinventing the wheel? One of the subfields in geroscience was born from the idea that some drugs currently in use for various indications might slow aging. In recent years,...
Fat and lean mice
In GeroScience, researchers have described how turning off a specific protein prevents mice from getting obese in old age. Mimicking hypoxia Hypoxia-inducible factors (HIFs) are a collection of three proteins that are sensitive to oxygen, and, like their name suggests, they normlly activate when a cell is operating in a low-oxygen environment. The gene EGLN1...
Insilico Medicine
In a new paper, InSilico has reported on its impressive success with a drug against idiopathic pulmonary fibrosis that was created by AI “from A to Z” and is currently in Phase 2 trials [1]. AI against aging Many people in the longevity community hope that the might of AI will help us to untangle...
Human lungs
The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...
Vitalia
Vitalia, the longevity pop-up city that came into being earlier this year on the island of Roatan off the coast of Honduras, was a first-of-its-kind event that we will more extensively cover later. Today, we are happy to present a roundup of the talks from the longevity biology conference held in Vitalia on the 23rd...