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Underdog Pharma
The investment company Kizoo has announced that one of the companies in its portfolio, Underdog Pharmaceuticals, has received $10 million in funding from a Series Seed II round. Mike Kope, who is well-known for his work in SENS Research Foundation, is the co-CEO of Underdog. As we have previously reported, this company is focused on...
Protein
Changing a single amino acid in a single protein boosts the fidelity of protein synthesis, and that is enough to increase lifespan in a variety of organisms, according to new research [1]. Proofreading proteins The loss of proteostasis is one of the hallmarks of aging. However, much of the research on the topic has focused...
Levine Interview
In her lab at Yale, Dr. Morgan Levine tackles some of the most exciting and difficult problems in geroscience. She specializes in bioinformatics and is working on creating and finessing clocks that measure biological age. We talked with Dr. Levine about her work, the impact that biological age clocks have had on the longevity field,...
Spinal Disc Degeneration
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause of disability [1]. Age-related disease with early onset Conventional wisdom says that our spines just were not built to last for as long as humans...
Aubrey de Grey EARD2021
At our fourth annual Ending Age-Related Diseases conference, Dr. Aubrey de Grey discusses the transition of rejuvenation biotechnology from proof-of-concept to companies engaging in clinical trials, and he outlines the challenges inherent in such a move.  Script It's great to be here, of course. I just thought I'd start by saying that some of...
Bone structure fails as we age but can be rejuvenated
Researchers have shown that age-related loss of bone maintenance is caused by changes in gene expression [1]. Perhaps most importantly, those changes can also be reversed and the bone marrow stem cells rejuvenated. Bones become weaker as we age as stem cell function declines With advancing age, it is typical for our bones to become...