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According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants [1]. Is it about amyloid beta? Despite billions of dollars invested in developing therapies against Alzheimer’s disease, the progress has been slow. The decades-old amyloid cascade hypothesis...

Like many people, I’m both wary of and intrigued by people who make bombastic claims. Years in the longevity field have taught me caution but also that big claims are not necessarily outlandish, and few people make bigger claims than Joshua “Scotch” McClure, founder and CEO of Maxwell Biosciences. The company developed Claromers™, a proprietary...

In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles. In the future, this technology could facilitate the creation of synthetic cells for various research, diagnostic, and therapeutic applications [1]. Paperless origami DNA and RNA molecules are central to life, carrying essential genetic information for...

Researchers publishing in Nature Communications have found that p53, a biomarker and inducer of senescence, suppresses both inflammation and DNA damage in senescent cells. Senescence against cancer Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...

Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus [1]. An essential protein Age-related decline in the function of the hypothalamus, a core region of the brain, has been suggested to be a “key factor in the development of whole-body aging” [2]. Due to...

A new study published in Nature Metabolism suggests that even a short period of eating loads of sweet and fatty snacks can cause brain changes reminiscent of those seen in obesity and type 2 diabetes [1]. What can go wrong in five days? If you usually eat healthy and take care of your body, there’s...