Help us: Donate
Follow us on:

Loss of IGF-1 May Contribute to Neurovascular Aging

IGF-1 seems likely to be one of many contributing factors.

brain vasculaturebrain vasculature

Researchers publishing in GeroScience have reported that the age-related decline in IGF-1 levels is associated with neurovascular aging [1].

IGF-1 and brain vasculature

This paper begins with a discussion of neurovascular coupling (NVC) and its relationship to vascular dementia. Blood flow to the brain is extremely important, both to provide active brain regions with oxygen and nutrients and to wash out toxic metabolites. Murine studies have shown that oxidative stress is connected with the disruption of this vascular system [2].

Separate murine studies have also shown that IGF-1 deficiency in mice results in impaired NVC [3] and that specifically disrupting this signaling results in an impaired NVC response [4]. However, these are still studies involving transgenic mice. These researchers, therefore, sought to determine if a relationship between IGF-1 and NVC in human beings could be determined.

A human analysis

For this study, the younger group consisted of people with an average age of nearly 30 years, and the older group consisted of 32 people with an average age of nearly 70 years. People with a wide variety of medical conditions, including any condition that could affect IGF-1, were excluded from participation.

There was no measured difference between the sexes in IGF-1 levels. However, there was a gulf between some participants and others of the same age; some younger people had substantial amounts of this molecule, while others had levels that were more similar to members of the older group.

As expected, the older group suffered from deficiencies in neurovascular coupling, as measured by the cerebrovascular conductance index. Cerebral vasculature normally significantly responds when the brain is being put to a task, but this response was significantly diminished in the older group compared to the younger group. The basal level of cerebral blood flow was also significantly decreased in the older group.

IGF-1 and neurovascular response were found to be weakly but significantly correlated, although many (but not all) younger participants with low IGF-1 levels still enjoyed much stronger task responses than their older counterparts with similar IGF-1 levels, in both halves of the brain.

This was not true for basal cerebral bloodflow, however. The correlation between IGF-1 and this measurement was somewhat stronger, and older and younger people with similar levels of IGF-1 often, but not always, had similar amounts of cerebral bloodflow.


While the animal studies might have pointed towards a causal relationship, this is still only a longitudinal study, so causation in human beings cannot be proved. Given the weak correlations, it is very likely that, even if there is a causal relationship, it is only one of many factors. However, in light of the extensive preclinical evidence, IGF-1 is clearly worth exploring as a druggable, therapeutic target, particularly as part of a combination therapy. Vascular dementia is a serious issue among the elderly, and if it can be slowed or halted, it might improve the quality and length of life for a great many people.

We would like to ask you a small favor. We are a non-profit foundation, and unlike some other organizations, we have no shareholders and no products to sell you. We are committed to responsible journalism, free from commercial or political influence, that allows you to make informed decisions about your future health.

All our news and educational content is free for everyone to read, but it does mean that we rely on the help of people like you. Every contribution, no matter if it’s big or small, supports independent journalism and sustains our future. You can support us by making a donation or in other ways at no cost to you.

Vitalik Buterin Exclusive Interview: Longevity, AI and More

Vitalik Buterin holding Zuzu, the puppy rescued by people of Zuzalu. Photo: Michelle Iai Don’t try finding Zuzalu on a...

Centenarians Have Slightly Different Gut Ecologies

Researchers publishing in Nature Microbiology have determined that the viruses populating the intestines of centenarians are slightly different from those...

Hypoxia Extends Median Lifespan in Fast-Aging Mice by 50%

Scientists have found that continuous oxygen restriction drastically extends the lifespan of progeroid mice, but the effect's mechanism remains a...

Discovering Why Adrenal Cancer Is More Dangerous for Women

A paper published today in Nature Aging has explained a relationship between cellular senescence, cancer of the adrenal glands, and...


[1] Toth, L., Czigler, A., Hegedus, E. et al. Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults. GeroScience (2022).

[2] Tarantini, S., Tran, C. H. T., Gordon, G. R., Ungvari, Z., & Csiszar, A. (2017). Impaired neurovascular coupling in aging and Alzheimer’s disease: contribution of astrocyte dysfunction and endothelial impairment to cognitive decline. Experimental gerontology, 94, 52-58.

[3] Toth, P., Tarantini, S., Ashpole, N. M., Tucsek, Z., Milne, G. L., Valcarcel‐Ares, N. M., … & Ungvari, Z. (2015). IGF‐1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging. Aging cell, 14(6), 1034-1044.

[4] Tarantini, S., Balasubramanian, P., Yabluchanskiy, A., Ashpole, N. M., Logan, S., Kiss, T., … & Ungvari, Z. (2021). IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging. Geroscience, 43(2), 901-911.

About the author
Josh Conway

Josh Conway

Josh is a professional editor and is responsible for editing our articles before they become available to the public as well as moderating our Discord server. He is also a programmer, long-time supporter of anti-aging medicine, and avid player of the strange game called β€œreal life.” Living in the center of the northern prairie, Josh enjoys long bike rides before the blizzards hit.
No Comments
Write a comment:


Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.