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Rejuvenation Roundup September 2022

This month features sponsorships, conferences, and methods of defeating senescent cells.

Rejuvenation Roundup thumbnail SeptemberRejuvenation Roundup thumbnail September
 

The spooky season is upon us again, so if you haven’t seen it yet, join us for a video on deadly but real zombies – and take a look at the most advanced research on how to get them out of our bodies.

LEAF News

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Team and activities

Life Noggin – The Zombie Problem: Life Noggin, part of the Lifespan.io family of Youtube channels, regularly makes videos on a variety of interesting topics and has just published a new video about aging! This time, its mascot, Blocko, stars in a new video featuring a problem that’s well known to regular Lifespan.io readers: senescent cells.

Stephanie Dainow Award WinnerResearch, DeSci, and Advocacy at Longevity Summit Dublin: It was all about collaboration: maybe not a lot of shiny new discoveries and unpublished data, but Longevity Summit Dublin 2022 brought together researchers, investors, and advocates to forge a common vision. More attention is being brought to the last category, as evidenced by our own executive director, Stephanie Dainow, receiving the Rising Star 2022 award.

Lifespan News

Big News for Mice: Ryan O’Shea reports different effects brought about by rapamycin and EGCG along with the NAD+ booster NR. Two new studies show that promising longevity interventions can regrow hair and combat hearing loss in mouse models.

LSN Longevity MassesSpreading Longevity: Ryan O’Shea discusses a new video in which Life Noggin and SENS have partnered to inform the public about rejuvenation biotechnology.

Multivitamins for Cognition: Ryan O’Shea discusses a study showing that taking multivitamins significantly improves human cognition. A new study shows that multivitamins can boost brain function, and the results are even more impactful for people with a history of heart disease.

Interviews

Evelyne Bischof InterviewProf. Evelyne Yehudit Bischof on Longevity Medicine: Evelyne Yehudit Bischof, MD, MPH, FEFIM, is a professor at Shanghai University of Medicine and Health Sciences, a visiting professor at Tel Aviv University School of Medicine, and chief physician for internal medicine in Renji University Hospital of Jiatong School of Medicine.

Rejuvenation Roundup Podcast

Ryan O’Shea of Future Grind hosts this month’s podcast, showcasing the events and research discussed here.

Advocacy and Analysis

Methuselah’s Zoo, a Look at Animal Longevity: To understand human longevity, we need to put it into perspective. Are we relatively long-lived or short-lived creatures? After all, among all the plants and animals in nature, we find a vast variety of lifespans, from several hours to several millennia, and possibly even more.

Research Roundup

No to sodaZero-Calorie Sweeteners Alter the Human Microbiome: A new open-label, randomized, controlled study published in Cell showed that zero-calorie sweeteners are metabolically active and some might impair glycemic response in healthy adults.

Two Small Molecules May Provide Partial Reprogramming: A preprint published in bioRxiv has detailed how partial reprogramming through two small molecules can rejuvenate human cells as well as C.elegans, a common model of aging. This paper begins with a discussion of the four well-known Yamanaka reprogramming factors (OSKM) that cause cells to revert to a previous epigenetic state.

Lab miceCanagliflozin Alleviates Several Aging Pathologies in Mice: Scientists have found that canagliflozin, an anti-diabetes drug that is known to extend lifespan in mice, alleviates an array of age-related pathologies, albeit in males only. Canagliflozin, a widely used anti-diabetes drug, belongs to the class of sodium glucose cotransporter 2 (SGLT2) inhibitors, which regulate glucose reabsorption by the kidneys.

Umbilical Plasma Injections Reduce Biological Age in Humans: Researchers have found that intramuscular injections of plasma concentrate made from human umbilical cord blood improve various health biomarkers and decrease biological age in elderly people. Circulating proteins have a significant impact on our health, and blood plasma transfusion is increasingly used against inflammatory conditions as well as some autoimmune disorders.

Smooth muscleMitochondrial Division Promotes Muscle Regeneration: A paper published in Cell Stem Cell has detailed how mitochondrial division is critical to the ability of muscle stem cells to regenerate damaged tissue. Quiescent muscle stem cells are held in reserve until injury causes them to form new somatic muscle cells

Brief Rapamycin Treatment in Early Adulthood Combats Aging: A study published in Nature Aging has shown that short-term rapamycin treatment in early adulthood extends lifespan in flies and improves gut health in both flies and mice. Rapamycin, an inhibitor of mTOR signaling, is capable of extending the lifespan of several organisms.

Skin fibroblastSenescence-Associated Protein Promotes Skin Aging in Mice: Researchers publishing in Aging have identified an individual protein, secreted frizzled-related protein 4 (SFRP4), that is produced by senescent cells and contributes to skin aging in mice.

Lactate Inhibits Tumor Growth in Mice: Publishing in Nature, scientists have found that sodium lactate boosts the T cell-mediated anti-cancer immune response, leading to significant inhibition of tumor growth.

Varied dietKetogenic and Mediterranean Diets Effective Against Diabetes: Pitting a ketogenic diet against a Mediterranean diet in pre-diabetes and Type 2 diabetes patients, scientists have learned that both confer metabolic benefits, but “keto” also has a darker side.

Injectable Cytokine Factories Eradicate Cancer in Mice: Researchers have succeeded in beating a type of cancer previously considered incurable by using microcapsules that contained live cytokine-producing cells. Interleukin-2 (IL-2) therapy was the first anti-cancer immunotherapy approved decades ago.

BrainwavesNeuromodulation Improves Memory in Older Adults: A new study published in Nature Neuroscience has shown that neuromodulation of low-frequency neuronal activity in the parietal cortex improved working memory, while high-frequency modulation in the prefrontal cortex improved long-term memory in older adults.

Removing Senescent Cells to Alleviate Muscular Dystrophy: A study published in Aging has shown that the removal of senescent cells through senolytics alleviates muscle degeneration in a mouse model of Duchenne muscular dystrophy. Duchenne muscular dystrophy is caused by a mutation that gradually destroys the muscles, eventually becoming fatal as it destroys the diaphragm or heart.

Dividing cellA Mitochondrial Protein Regulates Stem Cell Activity: Researchers publishing in Cell Stem Cell have found that the mitochondrial protein OPA1 is an integral, regulatory part of muscle stem cell activation, the process by which muscle stem cells proliferate and become active muscle tissue (myogenesis).

Multivitamin Supplementation Shown to Improve Cognition: In a large randomized, placebo-controlled study, scientists hoped that cocoa extract would improve cognitive function in elderly patients, but instead it was a multivitamin supplement that shined.

Severe brain diseaseA Review of Inflammation in Alzheimer’s and Parkinson’s: In the Journal of Inflammation, researchers from Johns Hopkins University have published a detailed review of the relationship between brain inflammation and the principal diseases of dementia. One out of twenty Americans over 85 have Parkinson’s disease, and seven out of twenty have Alzheimer’s.

Early-Onset Cancer Cases Are Rising: In a review paper published in Nature, scientists discuss the problem of the rising burden of early-onset cancer. We tend to think of cancer of a disease of aging, and for a good reason: cancer is indeed highly correlated with age.

muscle and boneOne Drug to Fight Both Sarcopenia and Osteoporosis: In a new study published in Bone Research, Japanese researchers established a novel drug screening system and identified a promising compound to treat age-associated muscle and bone frailty.

Transplanting B Cells from Old to Young Mice Improves Them: Researchers have recently explored why B cells become less efficient as we age, analyzing how their behavior changes when they are transplanted from aged mice into young mice.

Brain genesFundamental Metabolic Changes Accompany Alzheimer’s Disease: A paper published in Cell Metabolism has reported on a metabolic shift in neurons derived from patients with Alzheimer’s disease, showing that they express a cancer-like phenotype. Rather than attempting to harvest live neurons from Alzheimer’s patients, the researchers chose to create induced neurons (iNs) from the fibroblasts of these patients.

A High-Fat Diet Leads to Joint Degeneration in Rats: In a new study published in Scientific Reports, researchers have uncovered the molecular mechanism underlying the link between obesity and joint degeneration. Obesity accelerates aging and is associated with several age-associated diseases, including osteoarthritis, an inflammatory condition that leads to joint degeneration.

MicroplasticsNanoplastics Cause Mitochondrial Stress in Human Cells: A paper published in Environmental Science and Technology has described some of the effects of nanoplastics on human liver and lung cells. Plastics in the environment are gradually broken down by sunlight, grinding processes, and biological activities into smaller and smaller pieces.

A 2-year randomized controlled trial with low-dose B-vitamin supplementation shows benefits on bone mineral density in adults with lower B12 status: While low-dose B-vitamin intervention for 2 years had no overall effect, improving B-vitamin status appears to have specific benefits for adults with less B12.

Rapamycin treatment during development extends lifespan and healthspan of male mice and Daphnia magna: Short-term rapamycin treatment during development is a novel longevity intervention that acts by slowing down development and aging, suggesting that aging may be targeted early in life.

Metabolomic profiles predict individual multidisease outcomes: This study demonstrates both the potential and limitations of nuclear magnetic resonance-derived metabolomic profiles as a multidisease assay.

Young bone marrow transplantation prevents aging-related muscle atrophy in a senescence-prone mouse model: These findings suggest that this approach can prevent muscle wasting and dysfunction by mitigating apoptosis and proliferation via modulation of GDF-11 signalling and mitochondrial dysfunction in these mice.

Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice: Cardiac senescent cells accumulate in the aged female heart, and removing senescent cells is a key therapeutic target for efficient repair.

Senescence-Independent Anti-Inflammatory Activity of the Senolytic Drugs Dasatinib, Navitoclax, and Venetoclax in Zebrafish Models of Chronic Inflammation: Although these models do not manifest premature aging, the senolytic drugs dasatinib, navitoclax, and venetoclax have an anti-inflammatory effect that results in the amelioration of chronic inflammation.

Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice: Combinations of anti-aging drugs may have effects that surpass the benefits produced by either drug used alone, and additional studies of captopril, over a wider range of doses, are likely to be rewarding.

Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance: This study reveals dynamic remodeling of the brain immune cell landscape in aging and suggests senescent cell targeting as a strategy to counter inflammatory changes and cognitive decline.

News Nuggets

15th Gitcoin Funding Round Launches: Gitcoin has launched its 15th funding round and is again supporting projects focused on aging and rejuvenation. An alternative way to fund science Gitcoin is a platform focused on supporting the development of open-source Web3 software. This is a decentralized system based on blockchain technology with the goal of funding “public good” projects.

Longevity HackersFrom the Lab to the Big Screen: Longevity Hackers: In March 2022, VitaDAO uploaded the funding proposal VDP-39, Longevity Hackers Film Participation, initiating a discussion and vote on VitaDAO’s potential contribution to the project. On March 24th, this vote was passed, and the film’s team received $100,000 in donations from the DAO.

A Wearable Device to Monitor Metabolites and Nutrients: We want to highlight an interesting development on the wearable diagnostic front: researchers have developed a wearable device that can monitor nutrients, hormones, and drugs.

Magnitude BiosciencesMagnitude Reveals a New Target for Aging Therapeutics: At Longevity Summit Dublin, Ethan Perlstein and Magnitude Biosciences revealed that a small molecule, SMER28, improves longevity in C. elegans, a common model of aging.

Coming up

The Rejuvenation Startup Summit 2022, brought to you by the Forever Healthy Foundation, is a vibrant networking event that aims to accelerate the development of the rejuvenation biotech industry. Held in Berlin, the Summit will bring together startups, members of the longevity venture capital and investment ecosystem, and researchers interested in founding or joining a startup in the rejuvenation space. This event will start midday on Friday, October 14 and finish on the night of Saturday, October 15. Click here for a 20% discount!

NOVOS Longevity Tests

Join NOVOS for part 3 of 6 of the NOVOS Webinar Series: Longevity Tests: NOVOS will host a free 1-hour webinar with Founder and CEO Chris Mirabile on Wednesday, October 26th. CEO Chris Mirabile, serial entrepreneur and biohacking expert will focus on a range of tests to measure your longevity. He will discuss blood tests, DNA tests, epigenetic tests, microbiome tests, and more! Towards the end of the webinar, NOVOS will open the floor to questions. RSVP and submit questions today.

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