Thanksgiving is over, but we’re still thankful that so many people have decided to help stop the ravages of age-related disease by researching the causes of aging and joining the organizations needed to bring this research to people, and we’re definitely thankful for everyone who chooses to directly support us.
LEAF News
We would like to remind you once again that on January 26-28, 2021, the third annual Longevity Therapeutics Summit will commence! This fully online event will feature more than a hundred leaders in the longevity industry, including researchers and biotech executives, and will discuss ways to target, reverse, and delay the onset of age-related diseases.
Longevity Dialogues – Featuring Dr. Aubrey de Grey, Dr. Nir Barzilai and Keith Comito: Mark Sackler hosts a discussion focused on how to get the government and the general public on board with the idea of targeting aging directly to prevent age-related diseases.
Interviews
Breanna Deutsch Wants You to Contact Lawmakers About Aging: Coming from the world of political communications, Breanna Deutsch, author of Finding the Fountain, highlights the role of public comment in creating public policy.
Journal Club
Making Brain Cells Young Again: This research uses the Yamanaka factors (OSKM) to epigenetically return certain brain cells of mice to a youthful state, reversing many aspects of aging.
Rejuvenation Roundup Podcast
Ryan O’Shea of Future Grind hosts this month’s podcast, showcasing the events and research discussed here.
Helpful Information
Why I Hope to Be Alive at 75: Ezekiel Emanuel, the nation’s incoming COVID advisor, has expressed the opinion that it is a good idea to die at 75. Here, Editor-in-Chief Steve Hill disagrees with this method of dealing with age-related diseases.
Media Circus Surrounds Hyperbaric Oxygen Study: The media hype surrounding the results is nothing like the reality of the actual research paper, and this is another example of how shoddy journalism harms our field.
Send in the senolytics: Unity might have failed with UBX0101, but many other companies intend to make their own attempts at senescent cell removal, and Unity is trying again as well.
Research Roundup
The Extracellular Matrix Is Key to Heart Health: A new article sheds light on the differences between the extracellular matrix (ECM) of healthy people and people in end-stage heart failure.
C60 Does Not Improve Lifespan nor Healthspan: The findings of this study not only raise concerns about available C60 supplements, they also undermine the rationale for using them in the first place.
Researchers Use Lung Organoids to Study COVID: This highly impactful and timely research simultaneously makes major contributions to the field of lung regeneration and to our fight against the current global pandemic.
Aged Blood Makes Young Cells Old: Exposing young cells to aged blood causes their gene expression to become akin to aged cells.
Diluting Aged Blood Rejuvenates Old Brains: Aged blood can support rejuvenation if properly calibrated or, in this case, simply diluted.
Inflammation Decreases NAD+ During Aging: Researchers have discovered a link between senescent cells and the decline of NAD+ that occurs with aging.
Avoiding Osteoporosis with Alpha-Ketoglutarate: Research on rodents shows that alpha-ketoglutarate could be an effective way to treat or even prevent osteoporosis.
A New Scaffold for Liver Regeneration: This paper demonstrates that an alginate-gelatin-fibrin hydrogel formulation is a promising biomaterial for liver regeneration.
Gene Discovered to Alleviate Obesity: This particular gene removes some of the consequences of obesity without promoting actual weight loss.
Immune Protection for Insulin-Producing Cells: This is protection against the immune system, which both Type 1 and Type 2 diabetics need to retain working insulin-producing cells.
GrimAge Is the Best Clock for Predicting Death: Having an accelerated age according to the GrimAge epigenetic clock means that you are much more likely to die of any cause.
Linking Alzheimer’s Disease and Gut Bacteria: There is evidence that there is a bacterial element in some cases of Alzheimer’s disease, and a new study further reinforces this link.
Resveratrol Human Trial Results Published: The results of this study suggest that resveratrol may be beneficial for people suffering from heart failure.
Resveratrol improves motor function in patients with muscular dystrophies: Resveratrol decreases muscular and cardiac oxidative damage and improves conditions in animal models of muscular dystrophy.
The positive effect of spermidine in older adults suffering from dementia: The high dosage spermidine group results are far better than the achieved effects of currently available antidementia drugs. The placebo effect may be involved, so a follow-up study with a duration of 1 year is planned.
Physical activity and quality of life following astaxanthin in patients with heart failure: This compound was shown to increase self-reported physical activity and health-related quality of life in mental and physical ways.
Aspirin as a suppressor of cancer-related epigenetic aging: This study shows that, in colon tissue, methylation age in aspirin non-users increases with chronological age; however, in aspirin users, methylation age acceleration is suppressed according to epigenetic clocks.
Rapamycin-mediated mouse lifespan extension: Rapamycin at 42 parts per million in food increased survival significantly in both male and female middle-aged mice.
PPARγ agonists delay age-associated metabolic disease and extend longevity: One of these drugs reduces inflammation, fibrosis, and atrophy in aging tissues along with a host of other benefits.
Clinical Trial Examining Lactobacillus rhamnosus for Cognitive Functioning: Supplementation of this probiotic was associated with improved cognitive performance in middle-aged and older adults with cognitive impairment.
Senescent cell accumulation mechanisms inferred from parabiosis: Optimal treatments for removing senescent cells would match the time between treatments to the time it takes senescent cells to re-accumulate.
Circulating plasma factors involved in rejuvenation: This is a summary of blood factors that are associated with youthful and aged blood, including the effects of each one.
Telomerase improves motor function in a transgenic mouse model of Parkinson’s disease: Total, phosphorylated, and aggregated a-synuclein, which is associated with this disease, were significantly decreased in the hippocampus and neocortex of treated mice.
News Nuggets
OneSkin Has Released a Senotherapeutic Skin Cream: OneSkin recently released OS-01, a cosmetic skin care product that claims to reduce the activity of senescent cells according to typical cellular senescence biomarker
AI and Longevity Meet in a New Book: “Live Longer with AI” stretches far beyond the topic of AI and longevity to include everything from the basics of the biological machinery of aging to the ethics of immortality
Elevian Secures $15 Million in Equity Financing: This company is developing new drugs that can target the GDF11 pathway in order to spur rejuvenation of tissue.
Coming Up
Throughout this month, starting December 1st, we will be releasing a video from Ending Age-Related Diseases 2020 to the public! Subscribe to our YouTube channel to see the latest videos as they appear.