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Macrophages: Garbage Gobblers of the Immune System

Steve Hill
by
Steve Hill
February 1, 2017
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Macrophages (Greek: big eaters, from Greek μακρος (makros) = large, φαγειν (phagein) = to eat) are white blood cells that engulf and digest cellular debris, foreign substances, microbes, and cancer cells, and they modulate the immune system (in particular microglia – macrophages) using pro-youthful signalling.

One such effort in 2016 sent mesenchymal stem cells to the area of damage and resulted in a reduction of plaques in Alzheimer’s mice, as these stem cells reduce inflammation and encourage pro-youthful function via intracellular signaling [1].

Recently, researchers showed that delivering fresh, functionally young macrophages to the brain results in removal of the plaques (misfolded proteins) associated with Alzheimer’s disease [2].

This means that brain aging is not a one-way process and suggests that we might be able to use our own rejuvenated macrophages to treat this horrific disease and other, similar diseases, including heart disease and Parkinson’s, which also involve plaque accumulation.

Conclusion



Introducing youthful macrophages and boosting their efficiency represents a plausible pathway to treating age-related diseases, and the research world is currently investigating the potential of a number of therapies that do this.

Literature

[1] Naaldijk, Y., Jaeger, C., Fabian, C., Leovsky, C., Blüher, A., Rudolph, L., … & Stolzing, A. (2016). Effect of systemic transplantation of bone marrow‐derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer’s mice. Neuropathology and applied neurobiology.

[2] Daria, A., Colombo, A., Llobera, G., Hampel, H., Willem, M., Liesz, A., … & Tahirovic, S. (2016). Young microglia restore amyloid plaque clearance of aged microglia. The EMBO Journal, e201694591.

CategoryNews

 Tags: Immune system, Macrophages

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About the author
Steve Hill
   

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 600 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, as well as attending various medical industry conferences. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep me Prime, and New Economy Magazine. Steve is one of three recipients of the 2020 H+ Innovator Award and shares this honour with Mirko Ranieri – Google AR and Dinorah Delfin – Immortalists Magazine. The H+ Innovator Award looks into our community and acknowledges ideas and projects that encourage social change, achieve scientific accomplishments, technological advances, philosophical and intellectual visions, author unique narratives, build fascinating artistic ventures, and develop products that bridge gaps and help us to achieve transhumanist goals. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.
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