Tag: IGF-1

A team of Spanish researchers publishing in Aging have reported that they can delay reproductive senescence in female rats by stimulating the production of insulin growth factor 1 (IGF-1) through gene therapy. A well-studied approach IGF-1 is a well-known anti-inflammatory compound, having shown positive effects in human cells [1] and in mouse models [2]. In...

Researchers publishing in GeroScience have reported that the age-related decline in IGF-1 levels is associated with neurovascular aging [1]. IGF-1 and brain vasculature BrainThe brain is perhaps the most important organ in the body. While many organs are critical to our survival, the brain contains the self. It is responsible for personality and consciousness and...

A new meta-analysis from Aging Cell has shown that both high and low levels of IGF-1 are related to mortality risk [1]. Insulin-like growth factor 1 (IGF-1) IGF-1 is one of the body’s major metabolic hormones. It can have effects similar to insulin, and it mediates the effects of growth hormone. IGF-1 has growth-promoting effects...

Scientists have managed to extend the lifespan of C. elegans nematode worms by as much as 135% by blocking an insulin-related pathway very late in life [1]. The long-lived mutants Back in the late 80s and early 90s, experiments with C. elegans, tiny nematode worms, became one of geroscience's first major successes. Scientists showed that...

A recent study has shown that mice given selenium supplements were protected against the effects of a high-fat diet, similar to mice with a restricted methonine intake. Methonine restriction and caloric restriction It is well known among the longevity community that restricting calories leads to health benefits, and the practice of caloric restriction (CR) is...

Scientists have shown that insulin-like growth factor (IGF-1) mitigates age-related mitochondrial decline and cellular aging in cultured smooth muscular cells [1], although other studies paint a grimmer picture of IGF-1's effects. Mitochondrial decline and aging Mitochondria, dubbed "the powerhouses of the cell" for producing the bulk of the energy that our cells need to operate,...