Tag: Hallmarks of Aging

In Cell Stem Cell, a trio of reviewers has proposed five hallmarks that are specific to the aging of stem cells. Functional rather than molecular This review begins with a note that its classifications focus on the physical features and overall behavior rather than what is going on biochemically. This is because the hallmarks of...

The Hallmarks of Aging team has returned to Cell, publishing a detailed review discussing how future methods of dealing with aging might be highly personalized. Two more hallmarks? In the original and very heavily cited 2013 paper [1], Dr. López-Otín and colleagues outlined nine hallmarks of aging. In their 2023 update [2], three more were...

Researchers have published a review of the current state of combination therapies that address multiple Hallmarks of Aging [1]. Some of these combined therapies were found to induce greater lifespan extension than single treatments. A complex phenomenon calls for complex treatments The complexity of aging cannot be underestimated. It is unlike individual diseases, which primarily...

Dr. Michael Lustgarten delivers a clear and enlightening exploration of the intricate relationship between microbial burden and aging in Microbial Burden: A Major Cause of Aging and Age-Related Disease and What We Can Do to Fight Back! Through meticulous research and compelling analysis, the author sheds light on the profound impact of microbial burden and...

A review paper published in Cells has described multiple ways in which the secretion of extracellular vesicles (EVs) changes with aging, leading the authors to propose it as its own hallmark. Extracellular vesicles and their uses This review begins with an outline and explanation of extracellular vesicles and their classifications. Cells use extracellular vesicles to...

The year 2023 started with the publication of two remarkable review papers in Cell and Cell Metabolism by researchers addressing the hallmarks of aging and their interplay with the hallmarks of cancer [1,2]. These papers were authored by the same team that published the original 2013 Hallmarks of Aging paper [3]. The Reasons We Age...