The CellAge Database with Dr. João Pedro de Magalhães


Journal Club Joao Pedro de MagalhaesJournal Club Joao Pedro de Magalhaes

On Tuesday, June 30, the Journal Club returns, and our special guest Dr. João Pedro de Magalhães will be giving a talk and taking questions about the CellAge database.

Dr. João Pedro de Magalhães and his team at the University of Liverpool recently published a new study in which they used a systems biology approach to examine and better understand cellular senescence and its various pathways involved, which resulted in the creation of the CellAge database [1].

The CellAge database contains information about 279 genes that are linked to the process of cellular senescence. This resource will provide researchers with a valuable tool for better understanding aging and developing therapies that address cellular senescence.

We develop CellAge, a manually curated database of 279 human genes driving cellular senescence, and perform various integrative analyses. Genes inducing cellular senescence tend to be overexpressed with age in human tissues and are significantly overrepresented in anti-longevity and tumor-suppressor genes, while genes inhibiting cellular senescence overlap with pro-longevity and oncogenes. Furthermore, cellular senescence genes are strongly conserved in mammals but not in invertebrates. We also build cellular senescence protein-protein interaction and co-expression networks. Clusters in the networks are enriched for cell cycle and immunological processes. Network topological parameters also reveal novel potential cellular senescence regulators. Using siRNAs, we observe that all 26 candidates tested induce at least one marker of senescence with 13 genes (C9orf40, CDC25A, CDCA4, CKAP2, GTF3C4, HAUS4, IMMT, MCM7, MTHFD2, MYBL2, NEK2, NIPA2, and TCEB3) decreasing cell number, activating p16/p21, and undergoing morphological changes that resemble cellular senescence.

Join us on Tuesday, June 30 at noon EDT, 5 PM UK time on our Facebook page to catch the livestream, or if you are a Lifespan Hero, you can join us on the show; details on how to do that will be emailed to you.

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[1] Avelar, R. A., Ortega, J. G., Tacutu, R., Tyler, E. J., Bennett, D., Binetti, P., … & Shields, S. (2020). A multidimensional systems biology analysis of cellular senescence in aging and disease. Genome Biology, 21, 1-22.

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About the author

Steve Hill

Steve serves on the LEAF Board of Directors and is the Editor in Chief, coordinating the daily news articles and social media content of the organization. He is an active journalist in the aging research and biotechnology field and has to date written over 600 articles on the topic, interviewed over 100 of the leading researchers in the field, hosted livestream events focused on aging, as well as attending various medical industry conferences. His work has been featured in H+ magazine, Psychology Today, Singularity Weblog, Standpoint Magazine, Swiss Monthly, Keep me Prime, and New Economy Magazine. Steve is one of three recipients of the 2020 H+ Innovator Award and shares this honour with Mirko Ranieri – Google AR and Dinorah Delfin – Immortalists Magazine. The H+ Innovator Award looks into our community and acknowledges ideas and projects that encourage social change, achieve scientific accomplishments, technological advances, philosophical and intellectual visions, author unique narratives, build fascinating artistic ventures, and develop products that bridge gaps and help us to achieve transhumanist goals. Steve has a background in project management and administration which has helped him to build a united team for effective fundraising and content creation, while his additional knowledge of biology and statistical data analysis allows him to carefully assess and coordinate the scientific groups involved in the project.
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