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Tag: Vascular Aging

Capillaries
A new publication in Nature Aging has explained a great deal about aging of the neurovascular system, showing where and how the brain's blood supply changes with aging in a mouse model. A branching network of blood vessels In the neurovascular system, arteries lead to arterioles, which then branch off into precapillary sphincters. These lead...
Blood vessels brain
Researchers publishing in Aging have found that enlarged perivascular spaces (ePVS) in the brain are correlated with vascular disorders [1]. These spaces, which are part of the brain's glymphatic system, allow for the drainage of potentially dangerous metabolites such as beta amyloid [2]. A known biomarker of brain disorders As they become enlarged, perivascular spaces...
brain vasculature
Researchers publishing in GeroScience have reported that the age-related decline in IGF-1 levels is associated with neurovascular aging [1]. IGF-1 and brain vasculature BrainThe brain is perhaps the most important organ in the body. While many organs are critical to our survival, the brain contains the self. It is responsible for personality and consciousness and...
Vascular brain
A study published in Frontiers in Neurology has detailed how three well-known longevity-associated compounds affect vascular cognitive impairment (VCI) in a rat model. A rat model of a common human disease In bilateral common carotid artery occlusion (BCCAO), the arteries of rats are sutured to reduce blood flow. This mimics arterial occlusion in human beings...
Plastic for Dinner
Scientists have found that exposure to plastic nanoparticles drives cellular senescence and dysfunction in endothelial cells taken from a pig's coronary artery [1]. A widespread pollutant Plastic has changed the face of civilization, but the convenience of plastic comes at a price – mostly in terms of environmental pollution from plastic manufacturing and waste. There...
Brain Blood Vessels
After sifting through 1,600 FDA-approved drugs, scientists have shown that Viagra is significantly correlated with lower Alzheimer’s disease risk [1]. Re-repurposing Viagra? Viagra (sildenafil) is one of the most recognizable drugs in the world. Yet, sildenafil's hailed effect on erectile dysfunction was discovered serendipitously. Originally, sildenafil was studied as a candidate drug for heart-related chest...