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Tag: TORC1

Fruit flies
In a preprint paper, scientists have shown that treating drosophila flies and mice with rapamycin for a relatively brief period in early life mostly recapitulates the effects of a lifelong treatment, including lifespan extension in flies [1]. Rapamycin is considered one of the most promising geroprotective drugs. It belongs to a handful of molecules that...
Psoralea corylifolia
A new publication in Nature Communications has revealed that corylin, which is derived from the Chinese herb Psoralea corylifolia, increases the lifespan of model organisms through well-known pathways of aging. Finding corylin This study did not begin with an examination of corylin or even a look at this particular herb. Instead, the researchers examined multiple...
Small plate of food
A key gene mediating the effect of dietary restriction on longevity has been identified, improving our understanding of the link between the two and raising the prospect of more targeted therapeutic interventions. Less is more Dietary restriction is one of the most reliable ways to increase longevity, increasing lifespan in species from fruit flies to...
Disappointment
ResTORbio announced on Friday 15th that its current phase 3 drug trial for respiratory tract infections did not achieve its primary goal. The drug showed promise in earlier phases of testing, but sadly failed to reduce the incidence of respiratory tract infections in patients aged 65 and above. A setback for RTB101 This news has...
Rapamycin is a promising anti-aging therapeutic derived from a bacterium that was first found on Easter Island (it's named for Rapa Nui, the official name of Easter Island). It inhibits mTOR (mechanistic target of rapamycin), thus inhibiting the immune system response that would, in some cases, lead to organ rejection. This is the on-label, FDA-approved...

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