October 11, 2023
The Journal Club returns on Friday October 27th at 11:30 am Eastern time on the Lifespan.io Facebook page. We will be discussing the new paper from Conboy et al. which examines current DNA methylation clocks and their limitations in the context of aging. They also developed a "noise barometer" to measure the epigenetic impact of...
September 21, 2023
Publishing in Aging, the Conboy research lab has outlined the problems with existing machine learning-based clocks and created a new clock based on epigenetic noise. The problem with linear regression This paper begins with a description of the elastic net, an artificial intelligence algorithm that powers the majority of biological clocks, including the Horvath biological...
November 17, 2020
There has been a great deal of interest in the last few years in the potential regenerative properties of blood factors. This has led to two broad schools of thought: one in which there are regenerative factors in young blood that can be isolated, and another in which aged blood contains regenerative factors that cannot...
June 16, 2020
Back in 2005, Drs. Irina and Michael Conboy showed that joining the circulatory systems of young and old mice together in a procedure called parabiosis could rejuvenate aged tissues and reverse some aspects of aging in old mice. Following this discovery, many researchers concluded that there must be something special in young blood that was...
February 03, 2017
There has been a lot of interest in the idea that young blood transfused into an old person could be a way to regenerate tissues and reverse some of the damage caused by the aging process. Today a brand new podcast with Doctors Irina and Michael Conboy was brought to our attention, and we could...