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Tag: Idiopathic Pulmonary Fibrosis

Lung branches
A new review published in the American Journal of Respiratory Cell and Molecular Biology discusses the causes of, and potential treatments for, idiopathic pulmonary fibrosis (IPF). Fibrosis, but not focused on fibroblasts In the lungs, the trachea (airway) breaks out into a tree-like system of nodes. Each branch ends in alveoli, which are responsible for...
Lungs in orange
Scientists have successfully reversed persistent lung fibrosis in mice by overexpressing the SIRT3 protein in lung macrophages [1]. Fibrosis: not knowing when to stop Fibrosis may be the true apex predator of humanity. According to one study, fibrotic diseases that cause organ failure are responsible for around 45% of all deaths in the United States...
The Journal Club returns August 25th at 13:00 EDT live on our Facebook page where Dr. Oliver Medvedik will be taking a look at the new study by Dr. Maria Blasco from the CNIO, which shows that telomerase therapy can address fibrosis in normally aged mice and not just mouse models of the disease. Short/dysfunctional...
X-ray of fibrosis
Back in January 2018, researchers at CNIO reversed lung fibrosis in mice using a single gene therapy. Today, we want to spotlight a new study that builds on the positive results of the 2018 research, taking us another step closer to telomerase gene therapy in humans to reverse pulmonary fibrosis. The road to a gene...
For the January Journal Club, we discussed the recent human senolytics trial conducted at the Mayo Clinic. Abstract Background Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal cellular senescence-associated disease. Selectively ablating senescent cells using dasatinib plus quercetin...
The results from a human pilot study that focused on treating idiopathic pulmonary fibrosis with senescent cell-clearing drugs has been published. The drugs target aged and damaged cells, which are thought to be a reason we age and get sick, and remove them from the body. Senescent cells and aging As we age, increasing numbers...