April 08, 2024
Researchers publishing in the Journal of Clinical Investigation have developed a new method of screening for compounds, and they found one that appears to directly attack senescent cells involved in lung fibrosis. A disease of senescence What Are Senolytics? Senotherapeutics for Senescent CellsSenolytics work by targeting one of several pro-survival pathways that senescent cells use...
March 14, 2024
In a new paper, InSilico has reported on its impressive success with a drug against idiopathic pulmonary fibrosis that was created by AI “from A to Z” and is currently in Phase 2 trials [1]. AI against aging Many people in the longevity community hope that the might of AI will help us to untangle...
June 21, 2021
A new review published in the American Journal of Respiratory Cell and Molecular Biology discusses the causes of, and potential treatments for, idiopathic pulmonary fibrosis (IPF). Fibrosis, but not focused on fibroblasts In the lungs, the trachea (airway) breaks out into a tree-like system of nodes. Each branch ends in alveoli, which are responsible for...
February 23, 2021
Scientists have successfully reversed persistent lung fibrosis in mice by overexpressing the SIRT3 protein in lung macrophages [1]. Fibrosis: not knowing when to stop Fibrosis may be the true apex predator of humanity. According to one study, fibrotic diseases that cause organ failure are responsible for around 45% of all deaths in the United States...
August 18, 2020
The Journal Club returns August 25th at 13:00 EDT live on our Facebook page where Dr. Oliver Medvedik will be taking a look at the new study by Dr. Maria Blasco from the CNIO, which shows that telomerase therapy can address fibrosis in normally aged mice and not just mouse models of the disease. Abstract...
August 12, 2020
Back in January 2018, researchers at CNIO reversed lung fibrosis in mice using a single gene therapy. Today, we want to spotlight a new study that builds on the positive results of the 2018 research, taking us another step closer to telomerase gene therapy in humans to reverse pulmonary fibrosis. The road to a gene...