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Tag: Hallmarks of Aging

Elderly couple
March 04, 2021
A professor at the University of Southern California has proposed that longevity researchers expand their toolkit to include social hallmarks of aging [1]. This paper is one of a trio that offer a fresh perspective on geroscience by trying to integrate findings from a biological approach into the complex dynamics of humans as social animals....
February 24, 2021
A bold feature article published in Drug Discovery Today illustrates the coming of age of longevity pharmacology. Dr. João Pedro de Magalhães, one of the biggest names in longevity research, outlined some of the great strides taken in the last two decades, as various discoveries have been made in the biology of aging. Lifespan has...
Complicated machinery
February 12, 2021
Aging is a multifactorial and complex process; indeed, it is probably the most complex disorder known. It is made up of a combination of dozens of malfunctions locked together in an accelerating spiral of decline. Despite this undeniable complexity, which is captured to some extent by grouping the many age-related dysfunctions into nine categories often...
A depiction of NAD on a black background
February 05, 2021
Aging is accompanied by the loss of proteostasis, the accumulation of misfolded proteins and their amyloid aggregates, and mitochondrial dysfunction, which is partially characterized by the loss of mitochondrial homeostasis, the delicate balance that mitochondria need in order to produce energy without polluting the body with excessive amounts of free radicals. The hallmarks of aging...
August 10, 2020
Epigenetic alterations, which are one of the proposed reasons we age, are the changes to gene expression that our cells experience as we get older. These alterations harm the fundamental functions of our cells and can increase the risk of cancer and other age-related diseases. Depending on your view, epigenetic alterations are either the result...
Joao Pedro de Magalhaes at EARD2019
November 05, 2019
This is the final talk that we are releasing from Ending Age-Related Diseases 2019, our highly successful two-day conference that featured talks from leading researchers and investors, bringing them together to discuss the future of aging and rejuvenation biotechnology. João Pedro de Magalhães of the University of Liverpool discussed the genetic basis of aging and...