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Tag: C. elegans

Nematode
A study published in Redox Biology has reported that the upregulation of thioredoxin, a fundamental part of mitochondrial defense against reactive oxygen species, is associated with longevity in mutant C. elegans worms. Free radicals, revisited Why we Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and...
CBD oil
Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms. Two of the most well-known components of marijuana are tetrahydrocannabinol (THC) and cannabidiol (CBD). They have the same atomic composition, but differ in structure and in some of their qualities. THC is what...
Steven Austad
Dr. Steven Austad of the University of Alabama at Birmingham is not a typical geroscientist, or at least, he did not become one in a typical way. After obtaining his undergraduate degree in English literature, Steven spent several years on jobs such as a wild animal trainer for Hollywood before deciding to study biology, and his...
Nematode
Scientists have managed to extend the lifespan of C. elegans nematode worms by as much as 135% by blocking an insulin-related pathway very late in life [1]. The long-lived mutants Back in the late 80s and early 90s, experiments with C. elegans, tiny nematode worms, became one of geroscience's first major successes. Scientists showed that...
binary clock image
Scientists have devised a transcriptome-based aging clock that allows for precise measurement of biological age in C. elegans worms and shows promising results in humans as well [1]. The purpose of aging clocks One of the central questions of longevity research is how to measure biological age. If a pathology, genetic difference, lifestyle choice, or...
Jan Gruber and his team at Yale-NUS have recently completed a detailed set of studies looking at eleven of the most promising anti-aging single drugs, using nematode worms (C. elegans) as their model organism. Drug synergy found to increase lifespan in worms Even though testing the effects of single drugs on health and longevity in...