Tag: Amyloid-beta

A group of researchers has been able to ameliorate Alzheimer-like pathologies in mice by using a microtubule-stabilizing compound [1]. Cellular highways Microtubules (MTs) are tiny pipe-like structures that are made mostly of the polymerized protein tubulin. They constitute an important part of the cytoskeleton, a network of filaments that permeates the cell and performs many...

In a recent study, researchers from the Buck Institute have shown that cellular senescence, one of the hallmarks of aging, is partially responsible for Alzheimer's disease. Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially...

Through a new approach dubbed AMBAR, the biotechnology company Grifols has attempted to reduce the amount of harmful, Alzheimer’s disease-causing amyloid beta in the brain by collecting it with a blood protein called albumin and draining it out of the bloodstream. This approach differs from the previous antibody and catabody approaches and offers new hope...

In a study at King's College London, scientists have shown that a vicious circle in which the ill-famed amyloid-beta protein stimulates its own production might be a key factor in the etiology of neurodegeneration in Alzheimer's disease; furthermore, a drug known as fasudil seems to be effective against amyloid-beta in a mice model of the...

Today, we have an interesting study showing that the neuronal damage caused by beta-amyloid, which is associated with Alzheimer's disease, is repaired when the amyloid is removed [1]. This means that removing amyloid could potentially reverse the symptoms of Alzheimer's in the early stages of the disease before too much damage is done. Amyloids are misfolded...