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Tag: Amyloid Beta

Balanced stones
Scientists have demonstrated that “the Alzheimer’s allele” APOE e4 helps cognition earlier in life prior to the onset of the disease [1]. This might point at a possible reason for some aspects of aging. What makes us stronger kills us later The risk of developing Alzheimer's, one of the deadliest age-related diseases, is considerably elevated...
Journal Club
Journal Club returns on July 27th at noon Eastern / 17:00 UK live on our Facebook page. A new way to look at Alzheimer's The topic for this month will be a new study that challenges the amyloid hypothesis of Alzheimer's disease with new human data. The data suggests that the cognitive impairment that accompanies...
Solving brain puzzle
A recent study, led by the University of Cincinnati in collaboration with the Karolinska Institute in Sweden, challenges the popular amyloid hypothesis that has dominated Alzheimer’s research for decades. Amyloid accumulation may be the consequence, not the cause Over 100 years ago, Alois Alzheimer originally identified amyloid-beta plaques in the brains of people with the...
Mouse brain maze
According to a new study, Alzheimer’s disease is connected to inflammaging, which causes B-cells to change their phenotype and hamper amyloid-β (Aβ) removal [1]. Following successful experiments in vivo, the scientists propose B cell depletion as a possible therapy. The darker side of B cells    Alzheimer's disease (AD) is deadly, frustratingly resilient to treatment, and...
Alzheimer's disease
Until now, it was unclear as to whether drugs that clear amyloid, which accumulate in the brain during aging and accompany diseases such as Alzheimer's, have any influence over cognitive decline. Previous studies have aimed to find this out, but results have been inconclusive due to study designs, hard-to-interpret data, and other issues that muddy...
CGI of proteins walking
A group of researchers has been able to ameliorate Alzheimer-like pathologies in mice by using a microtubule-stabilizing compound [1]. Cellular highways Microtubules (MTs) are tiny pipe-like structures that are made mostly of the polymerized protein tubulin. They constitute an important part of the cytoskeleton, a network of filaments that permeates the cell and performs many...