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Tag: Age-Related Macular Degeneration

May 03, 2021
Following a significant adverse event in which a patient lost vision in an eye treated with ADVM-022, Adverum Biotechnologies has unveiled the details of its Phase 2 trial of this gene therapy for diabetic macular edema. An overgrowth of blood vessels Wet age-related macular degeneration (AMD) is caused when blood vessels from underneath the retina...
Elderly eyes
April 26, 2021
In a new paper published in Aging, researchers have determined that directly improving autophagy through flubendazole (FLBZ) is potentially useful in treating dry age-related macular degeneration (AMD), a disease that causes vision loss. An accumulation of lipids Dry AMD shares a surprising commonality with atherosclerosis. As our macrophages attack the fatty (lipid) deposits in our...
the retina
February 08, 2021
A review published in the Journal of Neuroinflammation explores the potential application of senotherapies, particularly in the context of treating age-related macular degeneration [1]. Introducing cellular senescence One of the most advanced approaches to treating aging and age-related diseases is that of addressing the presence of harmful senescent cells, which begin to accumulate with advancing...
Mouse eye
April 21, 2020
A group of researchers has succeeded in directly reprogramming fibroblast cells into photoreceptors and transplanting them into mice, which resulted in partial restoration of vision [1]. This achievement can potentially lead to the development of cheap and effective treatments for retinopathies such as age-related macular degeneration (AMD), the leading cause of vision loss in older...
July 26, 2018
Two studies by researchers at the University of Birmingham have shown that delivering drugs against the wet form of age-related macular degeneration (AMD) in the form of eyedrops might soon be possible in humans [1, 2]. What is age-related macular degeneration? AMD is a pathology of the retina, which is a light-sensitive tissue located in...