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Tag: Nuclear Lamina

January 07, 2021
A gene editing technique published in Nature has proven to be effective in a mouse model of Hutchinson–Gilford progeria syndrome (HGPS). A single error causes tremendous damage HGPS is a well-known disease that causes visible aging and early death in children. In progeria, the lamina that protects the genetic information in the nucleus is greatly...
October 15, 2020
A new study published in Nature shows a strong link between the protein G3BP1 and the SASP, a harmful byproduct of senescent cells.
June 19, 2020
LMNA, a gene coding for lamins, whose mutations cause many developmental diseases, is linked to Hutchinson-Gilford Progeria (HGP) [1]. HGP is a disease that causes premature aging and is currently affecting around 390 children. Their average life expectancy is around 13 years, but some affected individuals can live to 20 years. Nuclear lamins are fibrous...
December 04, 2019
If humans ever reach an average lifespan of well over 100 years, what is going to happen? Are we going to be bored with such long lives? "Well," says Prof. Brian Kennedy of the National University of Singapore, "If you ask me: 'Do I want to have cancer at 75? Do I want have Alzheimer’s...
February 20, 2019
Researchers at the Salk Institute have moved a step closer to a possible therapy for Hutchinson-Gilford progeria syndrome, a rare genetic disorder that is often described as accelerated aging, as people with it appear to age far faster than normal. Using a new CRISPR/Cas9 gene therapy in a mouse model, they were able to slow...
June 25, 2018
For the June edition of Journal Club, we discussed the recent paper entitled “Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver“. We had also summarized the research in an article earlier this month. Summary Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and...