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Tag: Neuroplasticity

Lab mouse
Molecular Psychiatry has recently published a report from the University of Cambridge detailing how the brain’s extracellular matrix (ECM) changes with age, negatively impacting memory, and how modifying the components of the brain ECM can revitalize memory in mice [1]. What is neuroplasticity? Neuroplasticity is the ability of neurons to form new connections. This ability...
Mouse back
A new study published in Cell Reports has shown that the senolytic navitoclax (ABT-263) helps mice heal from spinal cord injuries [1]. The difference between mice and zebrafish The zebrafish is a well-known species studied for its regenerative abilities, so the researchers began their investigation by examining what happens to the spines of mice and...
Synapses in the brain are preserved by transplanting young bone marrow into older individuals, according to an open-access mouse study published in Communications Biology. Blood and marrow Simply exchanging blood itself has been shown to have only limited positive effects on cognition. Irina and Michael Conboy have been performing plasma transfer experiments and experiments in...
Mouse brain maze
You know the story, and it happens to us all eventually: the older we get, the harder our brains find it to learn and remember new things. There are likely to be a myriad of reasons why the brain gets increasingly worse as we age, but these reasons are still poorly understood. Like the old...
Researchers from the Salk Institute have discovered that a protein called Chrdl1, secreted by astrocytes, is responsible for driving synapse maturation and limiting brain plasticity later in life [1]. Abstract In the developing brain, immature synapses contain calcium-permeable AMPA glutamate receptors (AMPARs) that are subsequently replaced with GluA2-containing calcium-impermeable AMPARs as synapses stabilize and mature....
As we age, our brains lose their flexibility; this, in turn, affects our ability to learn, to remember things and to adapt to new situations. The classic example is of older people who are stuck in a rut and unable to change how they think.Some people raise this possibility when any discussion of healthy, longer...