October 04, 2023
A recent study's authors investigated whether biomarkers measured earlier in life can predict if someone will live to their 100th birthday [1]. 35-year-long centenarian study Previous research has found that people who become centenarians have fewer disabilities, comorbidities, and hospitalizations earlier in life. They are also characterized by better cognitive functions than people who will...
September 21, 2023
Publishing in Aging, the Conboy research lab has outlined the problems with existing machine learning-based clocks and created a new clock based on epigenetic noise. The problem with linear regression This paper begins with a description of the elastic net, an artificial intelligence algorithm that powers the majority of biological clocks, including the Horvath biological...
September 05, 2023
The Biomarkers of Aging Consortium, an initiative uniting about 200 geroscientists around the goal to inform and guide the use of biomarkers of aging, has put out its first paper [1]. The need for biomarkers Since studies with lifespan as their endpoint can take a prohibitively long time, especially in humans, the importance of reliable...
August 17, 2023
Researchers publishing in Biogerontology have tested multiple biomarkers in an effort to use them as proxies for aging, and some of their findings were surprising. A simple study with direct measurements Unlike other association studies that are used to evaluate biomarkers of aging, this study did not use data from a pre-existing biobank or related...
July 21, 2023
A group of researchers led by Morgan Levine of Altos Labs has created a set of methylation clocks that can detect various aging patterns [1]. The less-than-perfect revolution The discovery that genome methylation patterns correlate with various processes of aging led to the development of methylation (epigenetic) clocks. They first appeared more than a decade...
May 02, 2023
A twin study published in GeroScience has yielded results suggesting that calcium channel blockers, drugs that are commonly used to treat hypertension and other diseases, slow down epigenetic aging and may lengthen healthy lifespan. A wide field The researchers begin this paper by noting that over 400 compounds, as found in the DrugAge database, have...