May 05, 2020
In this Journal Club, Dr. Michael Lustgarten from the Nutrition, Exercise Physiology, and Sarcopenia (NEPS) Laboratory at the HNRCA discusses the nine biomarkers of Levine's Phenotypical Age Calculator, how they relate to mortality, and what he recommends doing in order to optimize them for long-lasting youth. If you would like to check out the slides...
April 17, 2020
A new study reviews the state of the art of aging biomarkers and explores the future development of even better ways of measuring biological age. The need for better aging biomarkers Human life expectancy has been increasing throughout the 20th and 21st centuries due to improvements such as better access to healthcare and sanitation, lower...
February 25, 2020
Recently, researcher Dr. Alexey Moskalev has published a mini review that takes a look at aging biomarkers and how some of them compare with each other [1]. A major challenge in developing therapies that target the aging processes in order to prevent or reverse age-related diseases is having accurate ways to determine if a therapeutic...
February 11, 2020
At the recent Longevity Therapeutics Conference in San Francisco, we had the chance to interview Lewis Gruber of SIWA Therapeutics and discuss his company's senotherapeutic approach to cancer and senescent cells. He was accompanied by his wife, Misty, who is the CFO of SIWA. Many of our readers are familiar with CAR-T immunotherapy, which has...
December 05, 2019
A type of artificial intelligence technique is now being used to develop new drugs and therapies and could perhaps even help to solve aging. An urgent need for aging biomarkers There has long been an urgent need in our field to develop increasingly accurate biomarkers of aging so that the efficacy of interventions can be...
November 29, 2019
A team of researchers, including Drs. Vadim Gladyshev and Steve Horvath, recently published a review of DNA methylation aging clocks, which use biomarkers to determine the biological age of a person. Aging causes epigenetic alterations to occur, including changes to DNA methylation, histone modification, transcriptional alterations (variance in gene expression), and remodeling of chromatin (a...
