Tag: Alzheimer's

The pro-Alzheimer's allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before symptoms arise Alzheimer's disease begins long before symptoms appear, building silently for decades. The single strongest genetic risk factor for the common, late-onset form of...

Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a quarter of older people suffer from delirium after surgery [1], which rises to around half if the surgery is particularly invasive or high-risk [2]. This increases the length of hospital stays...

A new study has found a negative association between unprocessed meat consumption and cognitive decline in carriers of the “pro-Alzheimer’s” APOE ε4 allele. This counterintuitive connection might have something to do with human evolution [1]. The meat connection The APOE gene, which produces apolipoprotein E, a protein central to lipid transport in the brain and...

Researchers publishing in Cell Reports Medicine have described the development of a lipid nanoparticle (LNP) that delivers mRNA to neurons in order to stop the formation of tau aggregates and fight Alzheimer's disease. Tau and amyloids Amyloid beta deposition between neurons and tau aggregation within neurons are both hallmarks of Alzheimer's disease, and evidence suggests...

A recent study suggests that cognitive enrichment throughout life is associated with reduced dementia risk, and it has the potential to delay the onset of dementia and mild cognitive impairment by five to seven years [1]. Cognitive stimulation Engagement in cognitively stimulating activities has been linked to lower dementia incidence, better cognitive function, and a...

Scientists have applied partial reprogramming to memory-encoding neurons (engrams) and achieved memory improvements in Alzheimer’s models and wild-type mice [1]. Rejuvenating neurons Partial cellular reprogramming, which uses certain factors to rejuvenate cells while maintaining their identity) has shown promise across various conditions and cell types, including neurons [2]. Rejuvenating these long-lived brain cells is imperative...