Tag: Alzheimer's

In Aging Cell, researchers have outlined the relationship between Alzheimer's, increased pain sensitivity, and the enzyme LPCAT2. Pain is among the earliest signs The key characteristics of Alzheimer's disease, such as cognitive decline and brain deterioration, are very well-known [1]. However, other symptoms, such as pain sensitivity, may precede these key manifestations, providing an early...

Scientists have demonstrated that short-term exposure to microplastics causes Alzheimer’s-like effects in mice expressing human APOE4 versus APOE3. These effects were sex-dependent, mirroring the disease in humans [1]. Microplastics and the brain Exposure to tiny particles that plastic products shed (microplastics) has been linked to increased mortality and diseases [2]. Microplastics are ubiquitous and enter...

Scientists have found a way to directly stimulate the assembly of Complex I in mitochondria, rescuing memory deficits in mouse models of Alzheimer’s and frontotemporal dementia [1]. Mitochondrial signal transducers Why We Age: Mitochondrial DysfunctionAs they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that...

Scientists have developed a potent diagnostic tool based on the vascular hypothesis for Alzheimer’s. It outperformed three current techniques and might offer clues to the mechanism behind the disease [1]. The blood flow hypothesis Traditionally, Alzheimer's disease has been associated with the presence of amyloid plaques and tau tangles in the brain: the amyloid cascade...

In a recent study, researchers identified the critical role that lithium plays in brain health and the development of mild cognitive impairment and Alzheimer’s disease. Supplementing with a lithium salt called lithium orotate can reverse many of its cognitive decline-related changes on the molecular and cellular levels [1]. The road less traveled Understanding the underlying...

Researchers publishing in Nature Aging have discovered how Alzheimer's-related protein aggregates are also related to senescent cells and osteoporosis. Beyond the brain Why We Age: Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of the root causes of...