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Tag: Altered Intercellular Communication

Coughing
A study published in Aging Cell has shown that senescent cells impact the way that CD4 T cells differentiate into types and that senolytics can restore this differentiation to a more youthful one. Not all T cells are the same CD4 T cells, often known as helper T cells due to their recruitment and signaling...
Bone Marrow
In a study published in Aging, researchers have found that younger hematopoietic cells can restore older hematopoietic cells through microvesicles, which are facilitators of intercellular communication. Why we Age: Altered Intercellular CommunicationAltered intercellular communication, as described in the Hallmarks of Aging, is the change in signals between cells that can lead to some of the...
The human thymus
Publishing in Nature Communications' Cell Death Discovery, a team of Chinese researchers has discovered a reason for thymic involution, the age-related decline of the thymus. Adaptive Immune SystemThe adaptive immune system is a complex mechanism protects us from threats, including viruses and cancer. T cells and B cells are the backbone of this system.Read More...
Intercellular Communication
Today, we want to highlight a recent review that charts the pro-inflammatory signals produced by senescent cells [1]. What is the senescence-associated secretory phenotype? As we grow older, an increasing number of aged cells in our body enter a state called senescence. At this point, the cells no longer divide and, under normal conditions, should...
Heart Inflammation
A team of Chinese researchers has outlined the cellular link between age-related inflammation (inflammaging) and the physical aging of heart muscle cells (cardiomyocytes). NLRP3 and why it matters We have previously discussed the NLRP3 inflammasome, which releases inflammatory cytokines upon exposure to irritants [1], including reactive oxygen species (ROS) [2]. The researchers hypothesized that ROS,...
Stem cell development
A new study published in the FASEB Journal shows how mesenchymal stem cells derived from adipose tissue (ADSCs) reverse some effects of aging in nearby cells. It's not the cells themselves, it's what they secrete The original and ongoing main purpose of stem cell therapies is to directly combat stem cell exhaustion: to replenish the...

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