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Tag: Altered Intercellular Communication

The human thymus
Publishing in Nature Communications' Cell Death Discovery, a team of Chinese researchers has discovered a reason for thymic involution, the age-related decline of the thymus. Adaptive Immune SystemThe adaptive immune system is a complex mechanism protects us from threats, including viruses and cancer. T cells and B cells are the backbone of this system.Read More...
Intercellular Communication
Today, we want to highlight a recent review that charts the pro-inflammatory signals produced by senescent cells [1]. What is the senescence-associated secretory phenotype? As we grow older, an increasing number of aged cells in our body enter a state called senescence. At this point, the cells no longer divide and, under normal conditions, should...
Heart Inflammation
A team of Chinese researchers has outlined the cellular link between age-related inflammation (inflammaging) and the physical aging of heart muscle cells (cardiomyocytes). NLRP3 and why it matters We have previously discussed the NLRP3 inflammasome, which releases inflammatory cytokines upon exposure to irritants [1], including reactive oxygen species (ROS) [2]. The researchers hypothesized that ROS,...
Stem cell development
A new study published in the FASEB Journal shows how mesenchymal stem cells derived from adipose tissue (ADSCs) reverse some effects of aging in nearby cells. It's not the cells themselves, it's what they secrete The original and ongoing main purpose of stem cell therapies is to directly combat stem cell exhaustion: to replenish the...
Elderly muscle
Muscular degradation with age isn’t the result of a decline in the intrinsic regenerative ability of muscles, according to new research [1].  Instead, sarcopenia is likely due to changes in the muscle microenvironment that reduce repair and regeneration. Declining muscles Age-related muscle loss can begin as early as a person’s fourth decade, and sarcopenia can...
The Golgi apparatus
A group of researchers has found that extracellular vesicles carrying a specific type of microRNA can attenuate age-related inflammation and increase immune response following flu vaccination in mice [1]. Extracellular vesicles (EVs) are an important part of intercellular communication. These tiny nanoscale bubbles are secreted by cells into the intercellular space and can carry various...