Tag: AKG

In the newest study by the Interventions Testing Program, 16α-hydroxyestriol and canagliflozin significantly increased lifespan in male mice but were deleterious for females [1]. The golden standard The Interventions Testing Program, now entering its 20th year, is a monumental undertaking by the National Institute on Aging aimed at rigorously testing compounds for their possible effects...

A commercially available alpha-ketoglutarate-based supplement has been shown to roll back biological age by 7 years on average in a retrospective human study [1]. Live slower, die later Though metformin and rapamycin are getting most of the attention in the longevity field today, alpha-ketoglutarate (AKG) has emerged as another candidate longevity drug. These three molecules have...

Alpha-ketoglutarate (AKG) has long been a popular sports supplement and is often used in the bodybuilding world, but interest in this molecule has now reached the aging research field due to its central role in metabolism. What is alpha-ketoglutarate? AKG is a naturally occurring endogenous intermediary metabolite and part of the Krebs cycle, which means...

Alpha-ketoglutarate (AKG) is a popular dietary and sports supplement frequently used in the bodybuilding world, but interest in this molecule has more recently reached the aging research field for its potential to slow down aging. AKG is a naturally occurring endogenous intermediary metabolite, which means that our own bodies create it, and is part of...

Research on rodents shows that alpha-ketoglutarate could be an effective way to treat or even prevent osteoporosis [1]. Feeling frail Osteoporosis increases the risk of bone fractures in older people, harming them as individuals and increasing the load on hospitals as the average age of the population rises. Finding ways to prevent bones from weakening...

A research team led by Dr. Brian Kennedy has shown that administration of alpha-ketoglutarate (AKG) improves both lifespan and healthspan in middle-aged mice. Modest increase in lifespan from Alpha-Ketoglutarate  For this study, the researchers administered a calcium salt of AKG, CaAKG, to 18-month-old male and female Black 6 mice, which represents the equivalent of human...