Month: April 2022

Scientists have shown that partial cellular reprogramming can significantly increase the already impressive regenerative capacity of the liver and protect this crucial organ from a potentially lethal injury [1]. Why can't we regrow limbs? Cellular reprogramming induces de-differentiation of somatic cells back into pluripotent stem cells: a 'factory reset' that erases cell-specific software and hence...

In a preprint published in bioRxiv, a team of Singaporean researchers, including Jan Gruber, has found that a combination of stem cell rejuvenation and senescent cell removal is synergistically more effective than either alone. Different but related aspects of aging Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent...

The risk of Alzheimer’s disease goes up with age, and the number of people living with Alzheimer's is growing. While it is known to be associated with the loss of proteostasis, it has also been found to be associated with epigenetic alterations. An advanced online preprint in bioRxiv was published by Dr. Morgan E. Levine...

In a preprint paper, scientists have shown that treating drosophila flies and mice with rapamycin for a relatively brief period in early life mostly recapitulates the effects of a lifelong treatment, including lifespan extension in flies [1]. Rapamycin is considered one of the most promising geroprotective drugs. It belongs to a handful of molecules that...

On this episode of Lifespan News, Ryan O'Shea discusses why some people involved in rejuvenation biotechnology don't want to be known as such. Script As we’ve seen, Altos Labs seems to be tackling aging, but they insist that they aren’t. And they aren’t the only ones. Multiple groups appear to be making strategic decisions to...

Nature Communications has recently published a paper discussing the genetic sources of C-reactive protein, a well-known biomarker of chronic inflammation. What is Inflammaging? Chronic Inflammation and AgingOne of the aging processes consists of a chronic, smoldering background of inflammation that researchers call “inflammaging”.Read More An extremely broad study with a wide variety of genes Pulling...