Month: August 2021

A team of Chinese researchers has outlined the cellular link between age-related inflammation (inflammaging) and the physical aging of heart muscle cells (cardiomyocytes). NLRP3 and why it matters We have previously discussed the NLRP3 inflammasome, which releases inflammatory cytokines upon exposure to irritants [1], including reactive oxygen species (ROS) [2]. The researchers hypothesized that ROS,...

A study published in Cell Reports has shown that early-life exposure to antibiotics that destroy the gut flora can harm the lifelong development of mice, including lifespan. Three groups with different microbiota To begin the study, the researchers fed 20 baby mice, as well as their mothers, amoxicillin and neomycin, and they established a control...

With so many health and disease outcomes connected to the biological aging processes, research into quantifying and tracking aging has surged in recent years due to the work of Steve Horvath, Morgan Levine, and others. Currently, epigenetic analysis of biological aging is thought to be the most comprehensive and accurate measurement of aging that is...

Probably best known for its presence in grapes and wine, this popular dietary supplement may have a few tricks up its sleeve. What is resveratrol? Resveratrol is a stilbenoid, a type of natural phenol. It is a phytoalexin, a growth-inhibiting substance created by plant tissues in response to injury or contact with pathogens such as...

Last week, a new study published in Aging reported similar mechanisms of TGF-ß2 and collagen on hair follicle aging, dermal papilla cell senescence, and in vitro spheroid formation. Aging hair follicles Hair follicles reside in the epidermal and dermal skin layers. At their base is the dermal papilla, where hair growth is controlled by dermal...

In a study published in Genome Biology, researchers explain how they are working to make CRISPR less prone to large, accidental deletions of genetic material [1]. A previously unknown large problem While this seems counterintuitive, previous technology only allowed for the ready identification of deletions below 100 base pairs. New technology has allowed for larger...