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Month: November 2019

Open doors
As many of you recover from enjoying Thanksgiving, we want to give a small update to the people we are most thankful to: our monthly patrons, the Lifespan Heroes. Without the continued support of the Heroes, quite simply, we could not continue to do the work we do; we could not report on the latest...
Rapamycin skin
The results of a small human clinical trial focused on skin aging have been published, and they are positive. A topical application of rapamycin, an FDA-approved drug that is used to combat organ rejection during donor transplants and targets the mechanistic target of rapamycin (mTOR) pathway, was tested to see if it had any effect...
Colombia
Recently, Libella Gene Therapeutics has announced that it will be running a patient-paid trial in Colombia with an eye-watering $1 million USD price tag on enrollment. Patient-paid trial likely to cause backlash The topic of patient-paid trials often stirs up considerable debate among the research community, regulatory authorities, and the general public, with many people...
gut brain axis diagram
The relationship between health and the microorganisms living in the gut has increasingly reached the spotlight in the last few years, and a new study led by researchers at Nanyang Technological University, Singapore (NTU Singapore) sheds more light on the gut microbiome and how it can influence aging. The gut microbiome The gut microbiome is...
Disappointment
ResTORbio announced on Friday 15th that its current phase 3 drug trial for respiratory tract infections did not achieve its primary goal. The drug showed promise in earlier phases of testing, but sadly failed to reduce the incidence of respiratory tract infections in patients aged 65 and above. A setback for RTB101 This news has...
SKM and OSKM
A recent open-access study published in Cell Stem Cell has shown that excluding Oct4 from the OSKM cocktail reduces epigenetic aberrations and off-target gene activation. Induced pluripotency and Yamanaka factors Pluripotent stem cells are cells that can become other cell types in the body; during natural development, they create differentiated stem cells and ultimately somatic...

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