As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical signals, collectively known as the senescence-associated secretory phenotype (SASP), which encourages nearby cells to enter the same senescent state. Their presence causes many problems: they degrade tissue function, increase chronic inflammation, and can even eventually raise the risk of cancer and other age-related diseases. A new class of drugs known as senolytics focuses on the destruction of these stubborn “death-resistant” cells in order to reduce inflammation and improve tissue function.
We have created a video that explains what senescent cells are and how they accumulate with age, and you can read more about them here.