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Unity Biotechnology senolytic drug UBX1325

UNITY is a biotech company working on the removal of senescent cells, which accumulate with age, drive chronic inflammation, and spur various age-related diseases.

Founded by Drs. Jan van Deursen, Judith Campisi, Nathaniel David, and Daohong Zhou, the company has been developing senolytic therapies that can purge senescent cells from the body without harming healthy cells. The idea is that removing these problem cells could help us to maintain health and remain free of disease as we grow older.

UNITY drug candidate UBX1325 targets specific members of the Bcl-2 family of apoptosis regulatory proteins which some senescent cells use to evade destruction and remain alive.

UBX1325 is being evaluated for the potential treatment of age-related diseases of the eye, including age-related macular degeneration (AMD), diabetic macular edema (DME), and proliferative diabetic retinopathy.

In July 2021 UNITY issued a press release announcing the 8-week preliminary results of a phase 1 study of UBX1325 in patients with DME and wet AMD. Although a safety study, the results showed that along with being safe, vision and structure also improved. This was followed up in October 2021, with the 12-week results showing sustained improvements in vision & structure. A phase 2a study has launched in DME and further wet AMD patients are being enrolled in the phase 1 study to support an eventual phase 2a study.

Website: UNITY Biotechnology

Phase 2a study in DME