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Insilico Medicine (Co-developed with Fosun) � QPCTL Inhibitor (Cancer treatment)

The drug is a first-in-class, orally available small molecule inhibitor of QPCTL, a regulator of the CD47-SIRPα axis, which is commonly referred to as the “don’t eat me” axis in cancer immunotherapy. The drug aims to inhibit QPCTL, causing a reduction or loss of the binding between CD47 and SIRPα, which could result in increased antibody-dependent cellular phagocytosis and neutrophil-induced cytotoxicity.