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Steve Horvath, Ph.D.

Steve Horvath

About Steve Horvath, Ph.D.

Dr. Horvath is a Professor of Human Genetics and Biostatistics at the David Geffen School of Medicine, University of California, Los Angeles. Dr. Horvath’s research lies at the intersection of aging research, epidemiology, chronic diseases, epigenetics, genetics, and systems biology. He works on all aspects of biomarker development with a particular focus on genomic biomarkers of aging. He developed a highly accurate multi-tissue biomarker of aging known as the epigenetic clock. Dr. Horvath developed systems biologic approaches such as weighted gene co-expression network analysis which lend themselves for integrating gene genomic data sets. These methods have been used for a broad spectrum of age-related diseases including neurodegenerative diseases, cancer, cardiovascular disease. Dr. Horvath received a Ph.D. in Mathematics from the University of North Carolina, Chapel Hill in 1995 and a Doctorate of Science in Biostatistics from the Harvard School of Public Health in 2000.

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Principal Investigator San Diego Institute of Science

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Epigenetic clocks are a way to measure biological age.
Epigenetic Clocks - What are they?
An epigenetic clock is a biochemical test that uses DNA methylation levels and accumulation of methyl groups on DNA to determine biological age. There are many different kinds of clocks, and these clocks are often considered to be the gold standard in aging biomarkers. Researchers are currently examining them as potential tools for uncovering the underlying mechanisms of aging, as biomarkers for anti-aging interventions, and as predictors of patient risk for morbidity and mortality.
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Steve Horvath

Steve Horvath on the Present and Future of Epigenetic Clocks

Dr. Steve Horvath hardly needs an introduction, so we will be brief: he is the inventor of the epigenetic clock and, currently, principal investigator at Altos Labs. We talked about the recent developments in this immensely important field, including pan-mammalian clocks, two-species clocks, and single-cell clocks, along with the challenges the field faces. You are...
Death clock

GrimAge Is the Best Clock for Predicting Death

A new study published in the Journals of Gerontology has shown that the epigenetic clock GrimAge is a strong predictor of the effects of aging, particularly all-cause mortality: the likelihood of dying from any cause. Did previous clocks use the wrong target? As the researchers explain, the first-generation epigenetic clocks of Drs. Horvath (who contributed...
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