Oki

About Oki

Dr. O'Connor was awarded his Master's degree at Northwestern Medical in 1999 for his work studying behavioral neuroscience in aged rodents. In 2005, at Baylor College of Medicine he received a PhD in Biochemistry for his work on proteins that regulate human telomeres. Postdoctoral research includes work at UC Berkeley on muscle stem cells and aging. Dr. O'Connor was a researcher and administrator at the SENS Research Foundation from 2010 through 2019 where he headed up the MitoSENS team from until 2016 when he took over oversight of SRF research as VP of Research with oversight over all intramural and extramural research. In 2019 he spun out a company, Cyclarity Therapeutics, to develop a drug targeting small toxic biomolecules that accumulate with age. CyclarityTx is located at the Buck Institute for Research on Aging.

Campaigns Supported

Successful

CellAge: Targeting Senescent Cells With Synthetic Biology

Designing better systems for detection and safe removal of dysfunctional “senescent” cells to improve health and treat age-related diseases.

171% Funded
$34,215 Funded
campaign
complete

Successful

OncoSENS Control ALT Delete Cancer

High-throughput screening of a library of diverse drugs to find treatments for ‘ALT’ cancers, those which rely on Alternative Lengthening of Telomeres.

120% Funded
$72,002 Funded
campaign
complete

Successful

The Major Mouse Testing Program

Testing a new class of compounds, Senolytics, on their ability to extend healthy lifespan by clearing out dysfunctional cells in the body.

115% Funded
$52,075 Funded
campaign
complete

Successful

MitoSENS Mitochondrial Repair Project

Engineering backup copies of mitochondrial genes to place in the nucleus of the cell, aiming to prevent age-related damage and restore lost mitochondrial function.

153% Funded
$46,128 Funded
campaign
complete

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Related Topics

Why we Age: Mitochondrial Dysfunction

As they age, the mitochondria in our cells lose their ability to provide cellular energy and release reactive oxygen species that harm cells and cause increasing levels of systemic inflammation.
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Michael Lustgarten Fights Back Against Microbes
Dr. Michael Lustgarten delivers a clear and enlightening exploration of the intricate relationship between microbial burden and aging in Microbial Burden: A Major Cause of Aging and Age-Related Disease and What We Can Do to Fight Back! […]
Stabilized Vitamin C Improves Brain Aging in Mice
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Bryan Johnson Thinks AI Should Run Your Life
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Giving Old Stem Cells Lasting Youthful Powers
Researchers publishing in Cell Proliferation have described factors that appear to give old muscle stem cells the ability to effectively proliferate and differentiate for a very long time. When renewal runs out Many of the problems that elderly people […]

How Metabolic Syndrome Makes Aging Worse
Metabolic syndrome drives many of the hallmarks of aging, and multiple hallmarks of aging drive metabolic syndrome in a vicious, accelerating cycle. Central obesity, high triglycerides, low HDL cholesterol, high blood pressure, and elevated fasting glucose comprise a cluster […]
Are There More Urgent Issues Than Aging?
When you discuss any major issue, sooner or later someone will say that there are more urgent issues than whatever it is you’re advocating for. Sometimes it may be true; other times, and probably most of the time, it’s a […]
Telling Genuine DAOs and Scams Apart
DAOs can be effective organizational structures. According to the latest figures, the total treasury of all DAOs (registered) is around $21 billion, indicating trust in an […]

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