Spiegel Research Lab
The Spiegel Research Lab is based at Yale University and is a centre of excellence for synthetic chemistry and its application in human biology. Led by Dr. David Spiegel, the lab is developing new kinds of custom molecules with the aim of using them to treat human diseases including age-related ones. Perhaps the most important work to come out of this lab is that of the crosslink breakers and glucosepane synthesis as part of ongoing efforts to develop drugs capable of breaking down the inflexible crosslinks that form in our tissues with age and contribute to stiffening the arteries. The work on crosslinks has now reached the point where it was possible to create Revel, a spinout biotech company to take glucosepane breakers to market. Ongoing projects range from synthetic reaction development and natural product synthesis to the construction of functional molecules capable of accomplishing specific biological tasks.