Leucadia Therapeutics is developing Arethusta, a device that fights Alzheimer’s by promoting the flow of cerebrospinal fluid (CSF) through the brain. Normal brain function generates toxic metabolites that, if allowed to accumulate, leads to the formation of amyloid aggregates and tangles. The cribriform plate, a porous bone that sits just above the nasal bridge, drains the CSF that contains these metabolites. However, aging and other damage can block this drainage system, leading to a build-up of toxins and ultimately to amyloidosis. Leucadia is developing a shunt-like device that is inserted into the cribriform plate in order to make the holes larger and thus increase the flow of CSF.