As the human body ages, the thymus begins to shrink, and fewer numbers of T cells are created and trained to fight. This structural decay of the thymus is one of the main reasons why we become increasingly vulnerable to infectious diseases, such as influenza and pneumonia. Intervene Immune is working on regenerating the human thymus so it produces immune cells again like it did in youth.
Dr. Greg Fahy has been working on rejuvenation of the thymus for a number of years and, in 2015, conducted a small-scale human trial to see if the earlier results in animals would translate to people. His approach focuses on the use of human growth hormone (HGH) and dehydroepiandrosterone (DHEA) to regrow the thymus. Intervene Immune is currently working with physicians to provide a complete program of treatment and monitoring for patients. Its website offers prospective patients a number to call and a contact form, and the company replies to them with details on where and how they can receive this therapy. While this is an off-label use of HGH and DHEA, these compounds have already been approved for other conditions.