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Tag: Yamanaka Factors

Gene activation
In a new study published in Aging Cell [1], researchers report that transient activation of the Yamanaka factor Oct4 allowed partial reprogramming of cells, which led to rejuvenation in these cells and in a mouse model of premature aging. Yamanaka Factors and Partial Cellular ReprogrammingDrs.Β Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4,...
George Church Interview
Professor of Genetics at Harvard Medical School, a veteran geroscientist, and a serial entrepreneur, George Church hardly needs an introduction. While we are always happy to discuss the present and future of geroscience with him, this interview focuses on the two gene therapy papers that he recently co-authored, which drew a lot of attention due...
Vittorio Sebastiano
Vittorio Sebastiano is an Associate Professor (Research) of Obstetrics and Gynecology at Stanford University and one of the most prominent scientists in the emerging field of cellular reprogramming. He is also co-founder and Scientific Advisory Board Chairman of Turn Biotechnologies, a cellular rejuvenation company based on the research done in Sebastiano’s Stanford lab. Turn recently...
Fluorescent cells
A team of Chinese researchers has described a novel method of illuminating pluripotent stem cells in a paper published in Aging. How and why Yamanaka Factors and Partial Cellular ReprogrammingDrs.Β Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic stem cells.Β While this discovery showed...
Genetic research
Scientists have shown that a single cycle of partial cellular reprogramming leads to various changes in the tissues, but about half of them gradually disappear after the treatment [1]. Permanent or transient? It has been known since 2006 that somatic cells can be reverted to a pluripotent stem cell-like state by overexpressing certain regulatory genes....
Spinal disc
Partial cellular reprogramming using Yamanka factors has become increasingly prominent in the world of aging research. A new study suggests that transient exposure to the Yamanaka factors might be the solution to intervertebral disc degeneration [1]. Partial cellular reprogramming with Yamanaka factors We have talked previously about Yamanaka factors and how exposure to them can...