Tag: Stem Cell Exhaustion

In Cell Stem Cell, a trio of reviewers has proposed five hallmarks that are specific to the aging of stem cells. Functional rather than molecular This review begins with a note that its classifications focus on the physical features and overall behavior rather than what is going on biochemically. This is because the hallmarks of...

Researchers publishing in Aging Cell have used single-cell transcriptomics to discover new insights into how neural stem cells (NSCs) change with aging. Adults do generate neurons The adult brain does generate new neurons [1], particularly in the hippocampus, the part of the brain responsible for memory formation [2]. Neurogenesis is limited to very specific niches,...

Scientists have created a new, highly effective method of tracing blood cells’ lineage. This can improve our understanding of clonal hematopoiesis and its impact on an aging organism [1]. Hostile takeover In the human body, a relatively small pool of hematopoietic stem cells (HSCs) sustains a system that produces 100-200 billion mature blood cells each...

A team of scientists has discovered that some hematopoietic stem cells (HSCs) lose their ability to differentiate into useful somatic cells and that removing those bad HSCs is beneficial. Blood creation diminishes with age Hematopoiesis refers to the production of blood cells, both white and red. HSCs, which create these blood cells, are known to...

Researchers have discovered a protein that is necessary for proper healing of damaged corneal tissue and that this protein decreases with age. Repairing a shield that is easy to damage The corneal epithelium covers the cornea, which focuses light onto the retina of the eye. Although it fulfills multiple protective functions, this tissue is not...

A review article published in Stem Cell Research & Therapy has described the ways in which mesenchymal stromal cells (MSCs) are being developed to treat diseases, including age-related diseases. A lack of clinical treatments The reviewers begin their paper by discussing the most common age-related diseases. Immune system problems such as multiple sclerosis [1], brain...